Calcium messenger system: an integrated view.

In this double-blind study, 56 adult psychoneurotic outpatients with a primary diagnosis of anxiety neurosis were randomly assigned to receive buspirone (N = 18), diazepam (N = 20), or placebo (N = 18) over a four-week period. A battery of tests administered weekly indicated that buspirone, a new agent not chemically related to any currently marketed drugs, was as effective an antianxiety agent as diazepam and produced no more and perhaps fewer side effects. Buspirone showed excellent antidepressant effects as well. If further studies confirm the authors' findings and determine that buspirone does not result in tolerance and addiction, it would be more advantageous than the benzodiazepines in the treatment of anxiety.

Mechanisms of action of transmitters and other substances on smooth muscle.

Effects of prostaglandins E1, E2, A1, and F1-alpha on isolated vascular smooth muscle

Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells

Chemicals as tools in the study of excitable membranes.

Structure and function of the brain serotonin system

Synthetic [8-arginine]-vasopressin [8-lysine]-vasopressin [8-ornithine]-vasopressin or [2-phenylalanine 8-lysine]-vasopressin aggregated human platelets in heparinized platelet-rich plasma. The lowest effective concentrations (1-4mU/ml) caused a primary transient aggregation while higher concentrations also caused a secondary irreversible aggregation. Vasopressin was almost inactive in citrated platelet-rich plasma but caused aggregation in recalcified citrated or native material. Vasopressin also aggregated washed human platelets suspended in buffered saline if fibrinogen and either Ca2+ or Mg2+ ions were present. Ethylene glycol-bis (beta-aminoethyl ether)-NN-tetraacetic acid inhibited aggregation completely but only after preincubation with the platelets suggesting that platelet-bound calcium was also required. Phosphocreatine with creatine phosphokinase partially inhibited primary aggregation of platelets by vasopressin and prevented secondary aggregation which suggests that release of platelet ADP contributed to these processes. Concentrations of vasopressin causing irreversible aggregation released small amounts of 14C from platelets containing serotonin-14C. Platelet aggregation induced by vasopressin was inhibited by adenosine prostaglandin E1 N62-0-dibutyryl cyclic 35-AMP caffeine imipramine or N-ethylmaleimide. Adenosine and prostaglandin E each inhibited the action of vasopressin much more powerfully than that of ADP and therefore cannot act solely by inhibiting the effects of the ADP released. In several respects the effect of vasopressin on blood platelets resembled its action on smooth muscle. (Authors modified)

Endogenous prostaglandins and osmotic water flow in the toad bladder.

ARTICLESDissociation by lanthanum of smooth muscle responses to potassium and acetylcholineFR Goodman, and GB WeissFR Goodman, and GB WeissPublished Online:01 Mar 1971https://doi.org/10.1152/ajplegacy.1971.220.3.759MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByInterference of pentobarbitone with the contraction of vascular smooth muscle in goat middle cerebral artery12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 33, No. 1Metronidazole-induced myocardial depression: chemical and pharmacological studies on the role of calcium in-vitro12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 37, No. 3Contractile Action of Mn2+ via Ca2+ Channels Activated by Bay K 8644 in Guinea-pig Taenia Coli12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 50, No. 4Historical techniques: Cytosolic Ca2+ and contraction in smooth muscleTrends in Pharmacological Sciences, Vol. 25, No. 7The action of calcium antagonists on Ca2+ movements in isolated vesselsHistaminergic effect of crude papaya latex on isolated guinea pig ileal stripsPhytomedicine, Vol. 11, No. 1Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea-pigJournal of Ethnopharmacology, Vol. 66, No. 2Use of Lanthanum as a Tool to Delineate Calcium Mobilization Patterns in Smooth MuscleIon Channels as Targets for DrugsMuscle Relaxant Effects of a talantia roxburghiana on Intestinal Smooth Muscle27 September 2008 | International Journal of Pharmacognosy, Vol. 33, No. 2Inhibition of calcium-dependent contractions of the isolated guinea-pig ileal longitudinal muscle and taenia coli by the total glycosidic extract of the plant Sarcolobus globosusToxicon, Vol. 31, No. 1Effects of depolarizing concentrations of K+ and reduced osmotic pressure on 45Ca2+ accumulation by the rostral pars distalis of the tilapia (Oreochromis mossambicus)General and Comparative Endocrinology, Vol. 77, No. 2Interactions of Lanthanides with Tissues, Cells, and Cellular OrganellesRole of different calcium pools in the contraction of respiratory smooth muscleActa Physiologica Scandinavica, Vol. 124, No. 1Calcium channels in smooth muscleGastroenterology, Vol. 87, No. 4Time course of the spasmolytic effect of cadmium and cadmium uptake in guinea-pig taenia coliGeneral Pharmacology: The Vascular System, Vol. 15, No. 12 Calcium and Histamine Secretion from Mast CellsEFFECT OF LANTHANIDE IONS ON HISTAMINE SECRETION FROM RAT PERITONEAL MAST CELLS19 July 2012 | British Journal of Pharmacology, Vol. 72, No. 2The use of lanthanum and cytochalasin B to study calcium effects on skeletal muscle differentiation in vitroJournal of Cellular Physiology, Vol. 105, No. 3Differences in contractile responses to acetylcholine and serotonin in rat stomach fundus stripsEuropean Journal of Pharmacology, Vol. 65, No. 2-3Modification of Membrane Function by DrugsThe role of calcium and cyclic AMP in the contractile action of angiotensin II upon rat descending colonEuropean Journal of Pharmacology, Vol. 60, No. 2-3Methods of Measuring Intracellular CalciumModification of Membrane Function by DrugsCalcium Source for Contractile Response of Guinea Pig Taenia Caecum to Carbachol in a Calcium Deficient, Potassium Rich SolutionJapanese Journal of Pharmacology, Vol. 28, No. 4Interactions of Potassium, Noradrenaline and Acetylcholine in the Guinea Pig Vas DeferensActa Physiologica Scandinavica, Vol. 101, No. 4PROCEEDINGS OF THE British Pharmacological Society19 July 2012 | British Journal of Pharmacology, Vol. 61, No. 1EFFECTS OF DILTIAZEM AND LANTHANUM ION ON THE POTASSIUM CONTRACTURE OF ISOLATED GUINEA PIG SMOOTH MUSCLEJapanese Journal of Pharmacology, Vol. 27, No. 3EFFECTS OF SAMMARIUM (Sm3+) ON THE CONTRACTILITY OF ISOLATED GUINEA PIG VENTRAL TAENIA COLI TO HISTAMINEJapanese Journal of Pharmacology, Vol. 27, No. 4Investigation of the nature of differences between ?-adrenergic receptorsBulletin of Experimental Biology and Medicine, Vol. 79, No. 5Diphasic action of lanthanum in rat uterusPharmacological Research Communications, Vol. 7, No. 2Direct myocardial depressant effects of gentamicinEuropean Journal of Pharmacology, Vol. 30, No. 2The role of cyclic nucleotides in central synaptic function21 June 2005The Role of Cyclic Nucleotides in Central Synaptic FunctionCalcium regulation in the uterusPharmacology & Therapeutics. Part B: General and Systematic Pharmacology, Vol. 1, No. 4Alteration of Contractile Function and Calcium Ion Movements in Vascular Smooth Muscle by Gentamicin and Other Aminoglycoside AntibioticsAntimicrobial Agents and Chemotherapy, Vol. 5, No. 6Effects of Lanthanum on the Coupling between Membrane Excitation and Contraction of Isolated Frog Muscle FibresActa Physiologica Scandinavica, Vol. 90, No. 1Effect of lanthanum on 45Ca flux and secretion of protein from rat exocrine pancreasLife Sciences, Vol. 13, No. 7Quantitative aspects of drug-receptor interactionsJournal of Theoretical Biology, Vol. 40, No. 1The relaxing effect of aluminum and lanthanum on rat and human gastric smooth muscle in vitroEuropean Journal of Pharmacology, Vol. 22, No. 2Alterations in45Ca distribution and movements in ileal longitudinal smooth muscleAgents and Actions, Vol. 2, No. 5Effect of lanthanum on catecholamine release from adrenal medullaLife Sciences, Vol. 11, No. 20MEMBRANAL Ca++ TRANSLOCATION AND CHOLINERGIC RECEPTOR ACTIVATION More from this issue > Volume 220Issue 3March 1971Pages 759-766 Copyright & PermissionsCopyright © 1971 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1971.220.3.759PubMed4993569History Published online 1 March 1971 Published in print 1 March 1971 Metrics

Relationships between calcium and cyclic nucleotides in cell activation.

Periodicities in efferent discharge of splanchnic nerve of the cat.

Neuropeptides derived from pro-opiocortin: behavioral, physiological, and neurochemical effects.

Evidence for existence of alpha-adrenergic receptors in the mammalian trachea.

Cardiovascular purinoceptors

Changes in noradrenaline sensitivity and morphology of arterial resistance vessels during development of high blood pressure in spontaneously hypertensive rats.