Abstract

articleRegulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cellsT. F. McDonald, S. Pelzer, W. Trautwein, and D. J. PelzerT. F. McDonaldDepartment of Physiology and Biophysics, Dalhousie University,Halifax, Nova Scotia, Canada., S. PelzerDepartment of Physiology and Biophysics, Dalhousie University,Halifax, Nova Scotia, Canada., W. TrautweinDepartment of Physiology and Biophysics, Dalhousie University,Halifax, Nova Scotia, Canada., and D. J. PelzerDepartment of Physiology and Biophysics, Dalhousie University,Halifax, Nova Scotia, Canada.Published Online:01 Apr 1994https://doi.org/10.1152/physrev.1994.74.2.365MoreSectionsPDF (24 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Previous Back to Top Download PDF FiguresReferencesRelatedInformationCited BySERCA2a-phospholamban interaction monitored by an interposed circularly permutated green fluorescent proteinMaren E. Arnold, Wolfgang R. Dostmann, Jody Martin, Michael J. Previs, Bradley Palmer, Martin LeWinter, and Markus Meyer17 May 2021 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 320, No. 6Dehydroepiandrosterone inhibits ICa,L and its window current in voltage-dependent and -independent mechanisms in arterial smooth muscle cellsRikuo Ochi, Sukrutha Chettimada, Igor Kizub, and Sachin A. Gupte26 November 2018 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 315, No. 6Terpenoids with vasorelaxant effects from the Chinese liverwort Scapania carinthiacaBioorganic & Medicinal Chemistry, Vol. 26, No. 14Excitation and Excitation-Contraction Coupling of the Zebrafish Heart: Implications for the Zebrafish Model in Drug Screening30 May 2018Pharmacological Disruption of Sea Urchin Tube Foot Motility and BehaviorThe Biological Bulletin, Vol. 234, No. 2Protein phosphorylation maintains the normal function of cloned human Cav2.3 channels16 February 2018 | Journal of General Physiology, Vol. 150, No. 3Effects of seasonal acclimatization on thermal tolerance of inward currents in roach (Rutilus rutilus) cardiac myocytes23 September 2017 | Journal of Comparative Physiology B, Vol. 188, No. 2Relaxin influences ileal muscular activity through a dual signaling pathway in miceWorld Journal of Gastroenterology, Vol. 24, No. 8The role of S-nitrosylation of kainate-type of ionotropic glutamate receptor 2 in epilepsy induced by kainic acid26 December 2017 | Journal of Neurochemistry, Vol. 144, No. 3Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cellsMolecular Metabolism, Vol. 7Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine4 January 2018 | Pharmacology, Vol. 101, No. 3-4Expression of calcium channel transcripts in the zebrafish heart: dominance of T-type channels1 January 2018 | Journal of Experimental Biology, Vol. 53Protective role of the novel hybrid 3,5-dipalmitoyl-nifedipine in a cardiomyoblast culture subjected to simulated ischemia/reperfusionBiomedicine & Pharmacotherapy, Vol. 92Distribution and Regulation of L-Type Ca2+ Channels in Cardiomyocyte Microdomains20 September 2017Calcium handling precedes cardiac differentiation to initiate the first heartbeat11 October 2016 | eLife, Vol. 5Regulation of myofibroblast differentiation by cardiac glycosidesJennifer La, Eleanor B. Reed, Svetlana Koltsova, Olga Akimova, Robert B. Hamanaka, Gökhan M. Mutlu, Sergei N. Orlov*, and Nickolai O. Dulin*1 May 2016 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 310, No. 9Zebrafish heart as a model for human cardiac electrophysiology26 January 2016 | Channels, Vol. 10, No. 2PKA and phosphatases attached to the CaV1.2 channel regulate channel activity in cell-free patchesJianjun Xu*, Lifeng Yu, Etsuko Minobe, Liting Lu, Ming Lei, and Masaki Kameyama*15 January 2016 | American Journal of Physiology-Cell Physiology, Vol. 310, No. 2Low-Mg2+ treatment increases sensitivity of voltage-gated Na+ channels to Ca2+/calmodulin-mediated modulation in cultured hippocampal neuronsFeng Guo*, Pei-Dong Zhou, Qing-Hua Gao, Jian Gong, Rui Feng, Xiao-Xue Xu, Shu-Yuan Liu, Hui-Yuan Hu, Mei-Mi Zhao, Hogan-Cann Adam, Ji-Qun Cai, and Li-Ying Hao*15 April 2015 | American Journal of Physiology-Cell Physiology, Vol. 308, No. 8A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulationEtsuko Minobe*, Sachiko Maeda*, Jianjun Xu, Liying Hao, Asako Kameyama, and Masaki Kameyama1 December 2014 | American Journal of Physiology-Cell Physiology, Vol. 307, No. 11Electrical excitability of the heart in a Chondrostei fish, the Siberian sturgeon (Acipenser baerii)Thomas Eliot Haworth, Jaakko Haverinen, Holly A. Shiels, and Matti Vornanen1 November 2014 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 307, No. 9Electrical Excitation of the Heart in a Basal Vertebrate, the European River Lamprey ( Lampetra fluviatilis )Physiological and Biochemical Zoology, Vol. 87, No. 6The Roles of the RIIβ Linker and N-terminal Cyclic Nucleotide-binding Domain in Determining the Unique Structures of the Type IIβ Protein Kinase A11 August 2014 | Journal of Biological Chemistry, Vol. 289, No. 41Playing with Opening and Closing of Heterocycles: Using the Cusmano-Ruccia Reaction to Develop a Novel Class of Oxadiazolothiazinones, Active as Calcium Channel Modulators and P-Glycoprotein Inhibitors14 October 2014 | Molecules, Vol. 19, No. 10Modulation of L-type Calcium Current by Intracellular Magnesium in Differentiating Cardiomyocytes Derived from Induced Pluripotent Stem CellsStem Cells and Development, Vol. 23, No. 12Adenosine triphosphate regulates the activity of guinea pig Cav1.2 channel by direct binding to the channel in a dose-dependent mannerRui Feng, Jianjun Xu, Etsuko Minobe, Asako Kameyama, Lei Yang, Lifeng Yu, Liying Hao*, and Masaki Kameyama*1 May 2014 | American Journal of Physiology-Cell Physiology, Vol. 306, No. 9L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo FunctionFranz Hofmann, Veit Flockerzi, Sabine Kahl, and Jörg W. Wegener1 January 2014 | Physiological Reviews, Vol. 94, No. 1Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failureToshihide Kashihara, Tsutomu Nakada, Hisashi Shimojo, Miwa Horiuchi-Hirose, Simmon Gomi, Toshihide Shibazaki, Xiaona Sheng, Masamichi Hirose, Minoru Hongo, and Mitsuhiko Yamada15 April 2012 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 302, No. 8Atypical Ca2+ currents in chromaffin cells from SHR and WKY rat strains result from the deficient expression of a splice variant of the α1D Ca2+ channelPedro Segura-Chama, Claudia V. Rivera-Cerecedo, Ricardo González-Ramírez, Ricardo Felix, Jesús M. Hernández-Guijo, and Arturo Hernández-Cruz1 January 2012 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 302, No. 2Hypoxic Pulmonary VasoconstrictionJ. T. Sylvester, Larissa A. Shimoda, Philip I. Aaronson, and Jeremy P. T. Ward1 January 2012 | Physiological Reviews, Vol. 92, No. 1Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca2+ channelsTheodore M. Bartoletti*, Skyler L. Jackman*, Norbert Babai, Aaron J. Mercer, Richard H. Kramer, and Wallace B. Thoreson1 December 2011 | Journal of Neurophysiology, Vol. 106, No. 6Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase APimthanya Wanichawan, William E. Louch, Kristin H. Hortemo, Bjørg Austbø, Per Kristian Lunde, John D. Scott, Ole M. Sejersted, and Cathrine R. Carlson1 May 2011 | American Journal of Physiology-Cell Physiology, Vol. 300, No. 5Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytesMiwa Horiuchi-Hirose, Toshihide Kashihara, Tsutomu Nakada, Nagomi Kurebayashi, Hisashi Shimojo, Toshihide Shibazaki, Xiaona Sheng, Shiharu Yano, Masamichi Hirose, Minoru Hongo, Takashi Sakurai, Tetsuji Moriizumi, Hideho Ueda, and Mitsuhiko Yamada1 March 2011 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 300, No. 3Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channelsKai Guo, Xianming Wang, Guofeng Gao, Congxin Huang, Keith S. Elmslie, and Blaise Z. Peterson1 November 2010 | American Journal of Physiology-Cell Physiology, Vol. 299, No. 5Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractilityRavi Goyal, Ashwani Mittal, Nina Chu, Rebecca Afiba Arthur, Lubo Zhang, and Lawrence D. Longo1 November 2010 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 299, No. 5The β Subunit of Voltage-Gated Ca2+ ChannelsZafir Buraei, and Jian Yang1 October 2010 | Physiological Reviews, Vol. 90, No. 4α1-Adrenergic receptor subtype function in fetal and adult cerebral arteriesRavi Goyal, Ashwani Mittal, Nina Chu, Lubo Zhang, and Lawrence D. Longo1 June 2010 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 298, No. 6Maturation and the role of PKC-mediated contractility in ovine cerebral arteriesRavi Goyal, Ashwani Mittal, Nina Chu, Lijun Shi, Lubo Zhang, and Lawrence D. Longo1 December 2009 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 297, No. 6Activation of Phosphatidylinositol-Linked Novel D1 Dopamine Receptors Inhibits High-Voltage-Activated Ca2+ Currents in Primary Cultured Striatal NeuronsLi-Qun Ma*, Chao Liu*, Fang Wang, Na Xie, Jun Gu, Hui Fu, Jiang-Hua Wang, Fei Cai, Jue Liu, and Jian-Guo Chen1 May 2009 | Journal of Neurophysiology, Vol. 101, No. 5Ca2+ pathway involved in the refilling of store sites in rat adrenal medullary cellsHidetada Matsuoka, Keita Harada, Tomoya Ikeda, Kouta Uetsuki, Takeyoshi Sata, Akira Warashina, and Masumi Inoue1 April 2009 | American Journal of Physiology-Cell Physiology, Vol. 296, No. 4Genesis and Regulation of the Heart AutomaticityMatteo E. Mangoni, and Joël Nargeot1 July 2008 | Physiological Reviews, Vol. 88, No. 3Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulationXiongwen Chen, Xiaoying Zhang, David M. Harris, Valentino Piacentino, Remus M. Berretta, Kenneth B. Margulies, and Steven R. Houser1 May 2008 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 294, No. 5Cholesterol depletion modulates basal L-type Ca2+ current and abolishes its β-adrenergic enhancement in ventricular myocytesHiroto Tsujikawa, Yumei Song, Makino Watanabe, Haruko Masumiya, Sachin A. Gupte, Rikuo Ochi, and Takao Okada1 January 2008 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 294, No. 1Zn 2+ Sensitivity of High- and Low-Voltage Activated Calcium ChannelsBiophysical Journal, Vol. 93, No. 4Calcium and ArrhythmogenesisHenk E. D. J. ter Keurs, and Penelope A. Boyden1 April 2007 | Physiological Reviews, Vol. 87, No. 2Redox Control of Calcium Channels: From Mechanisms to Therapeutic OpportunitiesAntioxidants & Redox Signaling, Vol. 9, No. 4Transient Receptor Potential Channels in Cardiovascular Function and DiseaseCirculation Research, Vol. 99, No. 2Effects of caffeine, verapamil, lithium, and KB-R7943 on mechanics and energetics of rat myocardial bigeminiesE. Savio-Galimberti, and J. E. Ponce-Hornos1 February 2006 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 290, No. 2Involvement of Na+/Ca2+ exchanger in catecholamine-induced increase in intracellular calcium in cardiomyocytesHarjot K. Saini, Onkar N. Tripathi, Shetuan Zhang, Vijayan Elimban, and Naranjan S. Dhalla1 January 2006 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 290, No. 1Molecular Physiology of Cardiac RepolarizationJeanne M. Nerbonne, and Robert S. Kass1 October 2005 | Physiological Reviews, Vol. 85, No. 4Calmodulin interactions with IQ peptides from voltage-dependent calcium channelsD. J. Black*, D. Brent Halling*, David V. Mandich, Steen E. Pedersen, Ruth A. Altschuld, and Susan L. Hamilton1 March 2005 | American Journal of Physiology-Cell Physiology, Vol. 288, No. 3RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytesAtsuko Yatani, Keiichi Irie, Takayuki Otani, Maha Abdellatif, and Lei Wei1 February 2005 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 288, No. 2Calmodulin reverses rundown of L-type Ca2+ channels in guinea pig ventricular myocytesJian-Jun Xu, Li-Ying Hao, Asako Kameyama, and Masaki Kameyama1 December 2004 | American Journal of Physiology-Cell Physiology, Vol. 287, No. 6Modulation of Cav1 and Cav2.2 channels induced by nitric oxide via cGMP-dependent protein kinaseNeurochemistry International, Vol. 45, No. 6New Short Splice Variants of the Human Cardiac Cavβ2 SubunitJournal of Biological Chemistry, Vol. 279, No. 45Regional differences in L-type Ca2+ channel expression in feline lower esophageal sphincterAhmad Muinuddin, Youhou Kang, Herbert Y. Gaisano, and Nicholas E. Diamant1 October 2004 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 287, No. 4KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinaseLuke J. Janssen, Tracy Tazzeo, Jianmin Zuo, Evi Pertens, and Shaf Keshavjee1 October 2004 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 287, No. 4Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl? cotransport, intracellular Cl? and L-type Ca2+ channels4 August 2004 | Pfl�gers Archiv - European Journal of Physiology, Vol. 449, No. 1Sperm-specific protein kinase A catalytic subunit C 2 orchestrates cAMP signaling for male fertility31 August 2004 | Proceedings of the National Academy of Sciences, Vol. 101, No. 37Modulation of L-type Calcium Channels in Drosophila via a Pituitary Adenylyl Cyclase-activating Polypeptide (PACAP)-mediated Pathway16 June 2004 | Journal of Biological Chemistry, Vol. 279, No. 36Investigation of the effect of the c-kit inhibitor Glivec on isolated guinea-pig detrusor preparationsAutonomic Neuroscience, Vol. 115, No. 1-2Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell lineBiochemical Pharmacology, Vol. 68, No. 5Regulation of cardiac ion channels by signaling complexes: role of modified leucine zipper motifsJournal of Molecular and Cellular Cardiology, Vol. 37, No. 3Mitochondrial P2Y-Like receptors link cytosolic adenosine nucleotides to mitochondrial calcium uptake1 January 2004 | Journal of Cellular Biochemistry, Vol. 92, No. 5Temperature-independent Inhibition of L-Type Calcium Currents by Halothane and Sevoflurane in Human Atrial CardiomyocytesAnesthesiology, Vol. 101, No. 2Effect of ADP on Na+-Na+ Exchange Reaction Kinetics of Na,K-ATPaseBiophysical Journal, Vol. 87, No. 2A Model of the Rat Phrenic Motor NeuronIEEE Transactions on Biomedical Engineering, Vol. 51, No. 7Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic periodNoriko Niwa, Kenji Yasui, Tobias Opthof, Haruki Takemura, Atsuya Shimizu, Mitsuru Horiba, Jong-Kook Lee, Haruo Honjo, Kaichiro Kamiya, and Itsuo Kodama1 June 2004 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 286, No. 6Intracellular Ca2+ concentration and rate adaptation of the cardiac action potentialCell Calcium, Vol. 35, No. 6Pharmacological modulation of ion channels and transportersCell Calcium, Vol. 35, No. 6Analysing cardiac excitation–contraction coupling with mathematical models of local controlProgress in Biophysics and Molecular Biology, Vol. 85, No. 2-3Depolarization-induced calcium influx in rat mesenteric small arterioles is mediated exclusively via mibefradil-sensitive calcium channels29 January 2009 | British Journal of Pharmacology, Vol. 142, No. 4Regional expression of L-type calcium channel subunits during cardiac development1 January 2004 | Developmental Dynamics, Vol. 230, No. 1Selective block of swelling-activated Cl− channels over cAMP-dependent Cl− channels in ventricular myocytesEuropean Journal of Pharmacology, Vol. 491, No. 2-3Effects of volatile anesthetics on cardiac ion channelsActa Anaesthesiologica Scandinavica, Vol. 48, No. 5Electrophysiological properties of the L-type Ca2+ current in cardiomyocytes from bluefin tuna and Pacific mackerelH. A. Shiels, J. M. Blank, A. P. Farrell, and B. A. Block1 April 2004 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 286, No. 4Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling PathwaysANDRÁS SPÄT, and LÁSZLÓ HUNYADY1 April 2004 | Physiological Reviews, Vol. 84, No. 2Regulation of L-type calcium current by intracellular magnesium in rat cardiac myocytes23 February 2004 | The Journal of Physiology, Vol. 555, No. 2β- and α-adrenergic cross-signaling for L-type Ca current is impaired in transgenic mice with constitutive activation of εPKCBiochemical and Biophysical Research Communications, Vol. 314, No. 3Intracellular Ca2+ regulates responsiveness of cardiac L-type Ca2+ current to protein kinase A: role of calmodulinKenneth B. Walsh, and Qi Cheng1 January 2004 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 286, No. 1Molecular and functional insights into voltage-gated calcium channelsPharmacological characterisation of neuropeptide F (NPF)-induced effects on the motility of Mesocestoides corti (syn. Mesocestoides vogae) larvaeInternational Journal for Parasitology, Vol. 34, No. 1Physiological modulation of inactivation in L-type Ca 2+ channels: one switch12 January 2004 | The Journal of Physiology, Vol. 554, No. 2Effects of Na+/Ca2+ exchange induced by SR Ca2+ release on action potentials and afterdepolarizations in guinea pig ventricular myocytesC. Ian Spencer, and James S. K. Sham1 December 2003 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 285, No. 6Block of cardiac delayed-rectifier and inward-rectifier K + currents by nisoldipine2 February 2009 | British Journal of Pharmacology, Vol. 140, No. 5β-Adrenergic regulation requires direct anchoring of PKA to cardiac Ca V 1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 1520 October 2003 | Proceedings of the National Academy of Sciences, Vol. 100, No. 22Calcium sparks in mouse ventricular myocytes at physiological temperatureGregory R. Ferrier, Robin H. Smith, and Susan E. Howlett1 October 2003 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 285, No. 4Ca2+ channel characteristics in neuroendocrine tumor cell cultures analyzed by color contour plotsJournal of Neuroscience Methods, Vol. 129, No. 2Calcium bursts induced by nanosecond electric pulsesBiochemical and Biophysical Research Communications, Vol. 310, No. 2Modulation of manganese currents by 1, 4-dihydropyridines, isoproterenol and forskolin in rabbit ventricular cells25 June 2003 | Pflügers Archiv - European Journal of Physiology, Vol. 446, No. 6Apocalmodulin and Ca 2+ Calmodulin-Binding Sites on the Ca V 1.2 ChannelBiophysical Journal, Vol. 85, No. 3A Role for Ca2+ Stores in Kainate Receptor-Dependent Synaptic Facilitation and LTP at Mossy Fiber Synapses in the HippocampusNeuron, Vol. 39, No. 2Calcium Signaling and Uterine Contractility28 August 2016 | Journal of the Society for Gynecologic Investigation, Vol. 10, No. 5Muscarinic regulation of cardiac ion channels30 January 2009 | British Journal of Pharmacology, Vol. 139, No. 6Two Components of Voltage-Dependent Inactivation in Ca v 1.2 Channels Revealed by Its Gating CurrentsBiophysical Journal, Vol. 84, No. 6Potentiated L-type Ca2+ Channels Rectify12 May 2003 | Journal of General Physiology, Vol. 121, No. 6Cannabinoid Receptor Activation Differentially Modulates Ion Channels in Photoreceptors of the Tiger SalamanderAlex Straiker, and Jane M. Sullivan1 May 2003 | Journal of Neurophysiology, Vol. 89, No. 5Negative modulation of L-type Ca2+ channels via β-adrenoceptor stimulation in guinea-pig detrusor smooth muscle cellsEuropean Journal of Pharmacology, Vol. 470, No. 1-2The Voltage-sensitive Release Mechanism of Excitation Contraction Coupling in Rabbit Cardiac Muscle Is Explained by Calcium-induced Calcium Release28 April 2003 | Journal of General Physiology, Vol. 121, No. 5Is there an A-type K+ current in guinea pig ventricular myocytes?Ian Findlay1 February 2003 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 284, No. 2Kinases as therapeutic targets for heart failureNature Reviews Drug Discovery, Vol. 2, No. 2Modulation of L-type Ca 2+ channels in neonatal rat heart by a novel Ca 2+ channel agonistCanadian Journal of Physiology and Pharmacology, Vol. 81, No. 2Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?Journal of the American College of Cardiology, Vol. 41, No. 1Diltiazem Facilitates Inactivation of Single L-type Calcium Channels in Guinea Pig Ventricular MyocytesJapanese Heart Journal, Vol. 44, No. 6SELECTIVITY OF DIFFERENT CALCIUM ANTAGONISTS ON T- AND L-TYPE CALCIUM CURRENTS IN GUINEA-PIG VENTRICULAR MYOCYTESPharmacological Research, Vol. 46, No. 6Calcium-dependent inactivation and depletion of synaptic cleft calcium ions combine to regulate rod calcium currents under physiological conditions11 December 2002 | European Journal of Neuroscience, Vol. 16, No. 11Different Effects of Mibefradil and Amlodipine on Coronary Vessels and During β-Adrenergic Stimulation in Conscious DogsJournal of Cardiovascular Pharmacology, Vol. 40, No. 6β‐adrenergic and muscarinic agonists modulate inactivation of l‐type ca 2+ Channel Currents in Guinea‐Pig Ventricular Myocytes1 December 2002 | The Journal of Physiology, Vol. 545, No. 2Calcium-dependent inactivation of neuronal calcium channelsNature Reviews Neuroscience, Vol. 3, No. 11Effect of stimulation rate, sarcomere length and Ca 2+ on force generation by mouse cardiac muscle1 November 2002 | The Journal of Physiology, Vol. 544, No. 3Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2Nature, Vol. 419, No. 6910Ca 2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytesBritish Journal of Pharmacology, Vol. 137, No. 3L-Type Ca 2+ Channel Density and Regulation Are Altered in Failing Human Ventricular Myocytes and Recover After Support With Mechanical Assist DevicesCirculation Research, Vol. 91, No. 6Coupling of M2 muscarinic receptor to L-type Ca2+ channel via c-src kinase in rabbit colonic circular smooth muscleGastroenterology, Vol. 123, No. 3Comparative Capacitative Calcium Entry Mechanisms in Canine Pulmonary and Renal Arterial Smooth Muscle Cells1 September 2002 | The Journal of Physiology, Vol. 543, No. 3Structure of the voltage-gated L-type Ca 2+ channel by electron cryomicroscopy29 July 2002 | Proceedings of the National Academy of Sciences, Vol. 99, No. 16Regulation of the cardiac L-type Ca2+ channel by the actin-binding proteins α-actinin and dystrophinAbbas Sadeghi, Andrew D. Doyle, and Barry D. Johnson1 June 2002 | American Journal of Physiology-Cell Physiology, Vol. 282, No. 6Ionic mechanisms and Ca2+ regulation in airway smooth muscle contraction: do the data contradict dogma?Luke J. Janssen1 June 2002 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 282, No. 6Channels involved in transient currents unmasked by removal of extracellular calcium in cardiac cellsRegina Macianskiene, Francesco Moccia, Karin R. Sipido, Willem Flameng, and Kanigula Mubagwa1 May 2002 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 282, No. 5Phase I and phase II of short-term mechanical restitution in perfused rat left ventriclesCristian Dumitrescu, Prakash Narayan, Yuanna Cheng, Igor R. Efimov, and Ruth A. Altschuld1 April 2002 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 282, No. 4Regulation of cardiac and smooth muscle Ca2+channels (CaV1.2a,b) by protein kinasesKathleen D. Keef, Joseph R. Hume, and Juming Zhong1 December 2001 | American Journal of Physiology-Cell Physiology, Vol. 281, No. 6Regulation of ion channels by protein tyrosine phosphorylationMichael J. Davis, Xin Wu, Timothy R. Nurkiewicz, Junya Kawasaki, Peichun Gui, Michael A. Hill, and Emily Wilson1 November 2001 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 281, No. 5cGMP-mediated inhibition of cardiac L-type Ca2+current by a monoclonal antibody against the M2 ACh receptorJ. H. M. Nascimento, L. Sallé, J. Hoebeke, J. Argibay, and N. Peineau1 October 2001 | American Journal of Physiology-Cell Physiology, Vol. 281, No. 4Phosphorylation-dependent modulation of cardiac calcium current by intracellular free magnesiumSiegried Pelzer, Chicuong La, and Dieter J. Pelzer1 October 2001 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 281, No. 4Calcium waves induced by hypertonic solutions in intact frog skeletal muscle fibres1 October 2001 | The Journal of Physiology, Vol. 536, No. 2Local response of L‐type Ca 2+ current to nitric oxide in frog ventricular myocytes1 July 2001 | The Journal of Physiology, Vol. 534, No. 1Cyclic GMP regulation of the L‐type Ca 2+ channel current in human atrial myocytes1 June 2001 | The Journal of Physiology, Vol. 533, No. 2Modulation of the Ca 2+ ‐induced Ca 2+ release cascade by β‐adrenergic stimulation in rat ventricular myocytes1 June 2001 | The Journal of Physiology, Vol. 533, No. 3Hypoxia Alters the Sensitivity of the L-Type Ca 2+ Channel to α-Adrenergic Receptor Stimulation in the Presence of β-Adrenergic Receptor StimulationCirculation Research, Vol. 88, No. 10Stimulation of cardiac L-type calcium channels by extracellular ATPQi-Yi Liu, and Robert L. Rosenberg1 May 2001 | American Journal of Physiology-Cell Physiology, Vol. 280, No. 5Cardiac excitation-contraction coupling: role of membrane potential in regulation of contractionGregory R. Ferrier, and Susan E. Howlett1 May 2001 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 280, No. 5Sprint training shortens prolonged action potential duration in postinfarction rat myocyte: mechanismsXue-Qian Zhang, Lian-Qin Zhang, Bradley M. Palmer, Yuk-Chow Ng, Timothy I. Musch, Russell L. Moore, and Joseph Y. Cheung1 May 2001 | Journal of Applied Physiology, Vol. 90, No. 5Nifedipine blocks Ca 2+ store refilling through a pathway not involving L‐type Ca 2+ channels in rabbit arteriolar smooth muscle1 May 2001 | The Journal of Physiology, Vol. 532, No. 3Angiotensin II stimulates cardiac L-type Ca2+current by a Ca2+- and protein kinase C-dependent mechanismE. A. Aiello, and H. E. Cingolani1 April 2001 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 280, No. 4β‐Adrenergic receptor stimulation of L‐type Ca 2+ channels in rabbit portal vein myocytes involves both αs and βγ G protein subunits1 February 2001 | The Journal of Physiology, Vol. 531, No. 1Changes in [Na+]i, compartmental [Ca2+], and NADH with dysfunction after global ischemia in intact heartsSrinivasan G. Varadarajan, Jianzhong An, Enis Novalija, Steven C. Smart, and David F. Stowe1 January 2001 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 280, No. 1Effects of depolarization and low intracellular pH on charge movement currents of frog skeletal muscle fibersEdward M. Balog, and Robert H. Fitts1 January 2001 | Journal of Applied Physiology, Vol. 90, No. 1Simultaneous measurements of intracellular cAMP and L-type Ca 2+ current in single frog ventricular myocytes5 August 2004 | The Journal of Physiology, Vol. 530, No. 1Independent Modulation of L-type Ca2+ Channel in Guinea Pig Ventricular Cells by Nitrendipine and Isoproterenol.Japanese Heart Journal, Vol. 42, No. 6Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase CCirculation Research, Vol. 87, No. 12Hypoxia Increases the Sensitivity of the L-Type Ca 2+ Current to β-Adrenergic Receptor Stimulation via a C2 Region–Containing Protein Kinase C IsoformCirculation Research, Vol. 87, No. 12Evidence for functional role of εPKC isozyme in the regulation of cardiac Ca2+ channelsKeli Hu, Daria Mochly-Rosen, and Mohamed Boutjdir1 December 2000 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 279, No. 6Characterization of nifedipine-resistant calcium current in neonatal rat ventricular cardiomyocytesChristophe Pignier, and Daniel Potreau1 November 2000 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 279, No. 5Molecular determinant for run-down of L-type Ca 2+ channels localized in the carboxyl terminus of the α 1C subunit12 August 2004 | The Journal of Physiology, Vol. 529, No. 1Subcellular mechanisms of the positive inotropic effect of angiotensin II in cat myocardium1 November 2000 | The Journal of Physiology, Vol. 529, No. 1Tails of the L-Type Ca 2+ ChannelCirculation

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call