Abstract
Calcium homeostasis in red blood cells of dialysis patients in dependence of erythropoietin treatment
Highlights
Previous studies provided evidence for a massively increased intracellular Ca2+ concentration in red blood cells (RBCs) of patients with end-stage renal disease (ESRD) (Paschen et al, 1971; Gafter et al, 1989), whereas the dialysis procedure itself led in average to an even slightly decreased RBC’s Ca2+ content (Paschen et al, 1971; Długaszek et al, 2008)
The group of Florian Lang found an inhibition of non-selective cation channels by EPO with a decreased number of eryptotic red blood cells (RBCs) if patients were treated with EPO (Myssina et al, 2003)
Blood samples from healthy donors, end-stage renal disease (ESRD) patients and EPO treated ESRD patients were analyzed by fluorescence live cell imaging as previously described (Wang et al, 2013) (Figure 1)
Summary
Previous studies provided evidence for a massively increased intracellular Ca2+ concentration in red blood cells (RBCs) of patients with end-stage renal disease (ESRD) (Paschen et al, 1971; Gafter et al, 1989), whereas the dialysis procedure itself led in average to an even slightly decreased RBC’s Ca2+ content (Paschen et al, 1971; Długaszek et al, 2008). The group of Florian Lang found an inhibition of non-selective cation channels by EPO with a decreased number of eryptotic RBCs if patients were treated with EPO (Myssina et al, 2003). We investigated the free Ca2+ concentration in RBCs from ESRD (dialysis) patients under EPO treatment.
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