Abstract
Dissociated cells of the marine sponge, Microciona prolifera , aggregate in response to a species-specific aggregation factor (MAF) and Ca ionophores. We now report that leukotriene B 4, a 5-lipoxygenase product, also causes aggregation of sponge cells. No other lipoxygenase products provoked aggregation. However, nordihydroguaiaretic acid (NDGA), colchicine, indomethacin, piroxicam and ibuprofen inhibited MAF-induced aggregation; the latter three agents inhibited Ca movements. Inhibition of prostaglandin release cannot be the mechanism whereby these agents inhibit aggregation of sponge cells, since the cells do not respond to exogenous cyclooxygenase products.
Published Version
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