Abstract
Calcium carbonate microparticles with a size of 0.9 ± 0.2 μm containing a photosensitizer Photosens in a concentration of 2.0 ± 0.2 wt % were prepared by ultrasound-stimulated coprecipitation (20 kHz, 1W/cm2). It is shown that the encapsulated photosensitizer can be released by ultrasonic irradiation (0.89MHz, 1 W/cm2, 5 min) as a result of the destruction and recrystallization of calcium carbonate micro-particles. It is established that the combined ultrasonic (0.89 MHz, 1 W/cm2) and light (670 nm, 10 mW/cm2) in vivo influence on the transferred PC-1 strain tumors of rat liver containing intratumorally injected micro-containers with a photosensitizer gives rise to dystrophic changes in tumor cells and to the appearance of extensive necrotic centers, pointing to the presence of the evident destructive effect. Such microcontainers are proposed for use in treating external tumors or tumors accessible for ultrasonic and optical irradiation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
