Abstract
The contractile responses elicited from the nictating membrane of cats by postganglionic sympathetic nerve stimulation were decreased by fentanyl (10–20 μg/kg injected in the lingual artery). The inhibitory effect of fentanyl was preferential on responses elicited bu low frequency stimulation. Fentanyl (10–25 μg/kg) did not change the contractile responses to noradrenaline and tyramine. The inhibitory effect of fentanyl was antagonized by naloxone. Increases in plasma calcium concentration did not alter the contractile responses to symphatetic nerve stimulation but antagonized the inhibitory effect of fentanyl in a dose-depedent manner suggesting a possible competitive antagonism.
Published Version
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