Abstract
In toto mouse embryos were cultivated at embryonic day 8.5 for 26 h with 105, 310 or 620 μM caffeine; 105–310 μM correspond to concentrations transferred by the placenta of heavy caffeine consumers. Failure of neural tube closure, excessive proliferation of neuroepithelial cells and premature evagination of telencephalic vesicles were present in 50% of treated embryos. When reaching the embryonic neural tube before neuronal migration, caffeine regionally modifies the schedule and/or rate of neural cell proliferation.
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