Abstract
A highly efficient mechanochemical protocol for the synthesis of 2-arylbenzothiazole derivatives using substituted aromatic aldehydes and 2-aminothiophenol and caffeine hydrogen sulfate (CHS) as an eco-friendly catalyst was developed. The green protocol was performed efficiently at room temperature in solvent-free conditions using a grindstone method. The title compounds were obtained in high yields (85–93%) in less reaction time (2.5–5 min). The compounds were well characterized by spectral analysis. The present protocol has numerous advantages such as eco-friendly, excellent yield of products, solvent-free, reaction at room temperature, no tedious setup, high recyclability of catalyst, and easy workup. The CHS catalyst was reusable up to 5 times without appreciable loss of activity.
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