Abstract
A green and efficient synthetic protocol has been developed for the synthesis of a new series of substituted diethyl(((2-methoxy-5-(trifluoromethyl)phenyl)amino)(phenyl)methyl)phosphonates via a one-pot three-component reaction of 2-methoxy-5-trifluoromethyl aniline with various aromatic-substituted aldehydes and diethyl phosphite using meglumine sulfate as an eco-friendly catalyst at room temperature under solvent-free conditions. The merits of this method are high product yield, short reaction time, easy workup, and purification. All the synthesized compounds were evaluated for the antioxidant activity by DPPH, NO, and H2O2 methods using ascorbic acid as a standard. The compounds 4a and 4g showed the highest antioxidant activity than that of the standard ascorbic acid.
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