Abstract
Cadmium treatment of rats caused impairment of osteogenic potential of bone marrow mesenchymal stem cells: a possible mechanism of cadmium related osteoporosis
Highlights
Cadmium (Cd) which exists in the earth crust is released by industrial activity
In a recent study we showed that, the oral treatment of rats with 300 mg/kg/d of pnonylphenol for three mounts resulted in significant reduction of viability and proliferation ability of extracted bone marrow mesenchymal stem cells (MSCs) due to caspase dependent apoptosis
Cell viability determination using MTT colorimetric assay showed, after 21 d the viability of the MSCs extracted from Cd treated rats differentiated to osteoblasts was significantly reduced (P
Summary
Cadmium (Cd) which exists in the earth crust is released by industrial activity. The mechanism of cadmium induced osteoporosis is not well understood, so in this study, we examined the toxicity of bone marrow mesenchymal stem cell (MSCs) following treatment of rats with CdCl2 in drinking water, to revile the effect of this chemical on differentiation potential of MSCs. Methods: At the end of third passage, MSCs were grown in the osteogenic medium for 21 days. The mean bone matrix mineralization and intracellular calcium content of the MSCs reduced significantly (P
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
