Cadmium and High-Fat Diet Disrupt Renal, Cardiac and Hepatic Essential Metals

Jamie L Young,J Christopher States,Jianxiang Xu,Xiaofang Yan,Xiang Zhang,Gregory N Barnes,Maiying Kong,Lu Cai,Walter H Watson,Gavin E Arteel,Xinmin Yin,Jonathan H Freedman

doi:10.1038/s41598-019-50771-3

Jamie L Young, J Christopher States + Show 10 more

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https://doi.org/10.1038/s41598-019-50771-3

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Exposure to the environmental toxicant cadmium (Cd) contributes to the development of obesity-associated diseases. Obesity is a risk factor for a spectrum of unhealthy conditions including systemic metabolic dyshomeostasis. In the present study, the effects of whole-life exposure to environmentally-relevant concentrations of Cd on systemic essential metal distribution in adult mice fed a high-fat diet (HFD) were examined. For these studies, male and female mice were exposed to Cd-containing drinking water for >2 weeks before breeding. Pregnant mice and dams with offspring were exposed to Cd-containing drinking water. After weaning, offspring were continuously exposed to the same Cd concentration as their parents, and divided into HFD and normal (low) fat diet (LFD) groups. At 10 and 24 weeks, mice were sacrificed and blood, liver, kidney and heart harvested for metal analyses. There were significant concentration dependent increases in Cd levels in offspring with kidney > liver > heart. Sex significantly affected Cd levels in kidney and liver, with female animals accumulating more metal than males. Mice fed the HFD showed > 2-fold increase in Cd levels in the three organs compared to similarly treated LFD mice. Cadmium significantly affected essential metals levels in blood, kidney and liver. Additionally, HFD affected essential metal levels in these three organs. These findings suggest that Cd interacts with HFD to affect essential metal homeostasis, a phenomenon that may contribute to the underlying mechanism responsible for the development of obesity-associated pathologies.

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Exposure to the environmental toxicant cadmium (Cd) contributes to the development of obesityassociated diseases
Male mice fed high-fat diet (HFD) gained more weight compared to those fed LFD
Those exposed to 0 ppm Cd water and HFD gaining an average 0.42 grams more body weight per week compared to LFD fed male mice (Fig. 1)

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Introduction

Exposure to the environmental toxicant cadmium (Cd) contributes to the development of obesityassociated diseases. The effects of whole-life exposure to environmentallyrelevant concentrations of Cd on systemic essential metal distribution in adult mice fed a high-fat diet (HFD) were examined. For these studies, male and female mice were exposed to Cd-containing drinking water for >2 weeks before breeding. Cadmium significantly affected essential metals levels in blood, kidney and liver. HFD affected essential metal levels in these three organs These findings suggest that Cd interacts with HFD to affect essential metal homeostasis, a phenomenon that may contribute to the underlying mechanism responsible for the development of obesity-associated pathologies. There are sex-specific differences in essential metal dyshomeostasis[15]

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