Abstract
We have investigated the distribution of the sarcolemmal Ca 2+ transporters in hamster and dog ventricular myocytes by immunocytochemical and membrane fractionation techniques. The data suggest that the DHP receptor α1 subunit and the Na +/Ca 2+ exchanger are present in surface sarcolemma as well as T-tubule membranes located at the cardiac dyads. Compared with these Ca 2+ transporters, the sarcolemmal Ca 2+-ATPase is much less abundant in the latter fraction. Thus the sarcolemmal Ca 2+-ATPase seems to be located predominantly in surface sarcolemma.
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