Abstract
Ca(2+) and Ca(2+)-interlocked membrane guanylate cyclase signal modulation of neuronal and cardiovascular signal transduction.
Highlights
Duda T (2015) Ca2+ and Ca2+-interlocked membrane guanylate cyclase signal modulation of neuronal and cardiovascular signal transduction
The papers in this research topic are focused on the extraordinary tale of cyclic GMP: its recognition as a hormonal second messenger and its subsequent interplay with intracellular calcium where the two together become co-messengers in cellular signal transduction processes
Current research suggests that new developments will continue to follow a tortuous but always exciting path! Guanylate cyclase activating proteins or GCAPs are neuronal calcium sensing proteins that serve as subunits in the ROS-GC complex
Summary
Duda T (2015) Ca2+ and Ca2+-interlocked membrane guanylate cyclase signal modulation of neuronal and cardiovascular signal transduction. The papers in this research topic are focused on the extraordinary tale of cyclic GMP: its recognition as a hormonal second messenger and its subsequent interplay with intracellular calcium where the two together become co-messengers in cellular signal transduction processes. The topic introduces the present status of the field with a figure illustrating that cyclic GMP is generated by two structurally different guanylate cyclases, soluble and the membrane form (Figure 1: Sharma and Duda, 2014).
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