Abstract
The effect of C60 fullerene aqueous colloid solution (C60FAS) on the intensity of long‑lasting (persisting for one hour) rotational movements in non‑anesthetized rats was investigated. For this purpose, an experimental hemiparkinsonic animal model was used in the study. Rotational movements in hemiparkinsonic animals were initiated by the intraperitoneal administration of the dopamine receptor agonist apomorphine. It was shown that a preliminary injection of C60FAS (a substance with powerful antioxidant properties) in hemiparkinsonic rats induced distinct changes in animal motor behavior. It was revealed that fullerene‑pretreated animals, in comparison with non‑pretreated or vehicle‑pretreated rats, rotated for 1 h at an approximately identical speed until the end of the experiment, whereas the rotation speed of control rats gradually decreased to 20-30% of the initial value. One can assume that the observed changes in the movement dynamics of the hemiparkinsonic rats after C60FAS pretreatment presumably can be induced by the influence of C60FAS on the dopaminergic system, although the isolated potentiation of the action of apomorphine C60FAS cannot be excluded. Nevertheless, earlier data on the action of C60FAS on muscle dynamics has suggested that C60FAS can activate a protective action of the antioxidant system in response to long‑lasting muscular activity and that the antioxidant system in turn may directly decrease fatigue‑relate d changes during long‑lasting muscular activity.
Highlights
Skeletal muscles have large energy reserves for long‐term contractions, but excessive physical activi‐ ty leads to reduced muscle force contractions and fa‐ tigue development
In our previous electrophysiological and biochemical study, we investigated the effect of pris‐ tine C60 fullerene aqueous colloid solution (C60FAS) on fatigue of triceps surae (TS) muscles in rats induced by the intermittent high‐frequency electrical stimula‐ tion of the tibial nerve
The ani‐ mals began to rotate at a speed of 10–18 rotations per minute, and the rotations gradually decreased to the end of the experiment to 2–5 rpm and even to a complete stop; that is, the average number of rats revolutions decreased to 20–30%
Summary
Skeletal muscles have large energy reserves for long‐term contractions, but excessive physical activi‐ ty leads to reduced muscle force contractions and fa‐ tigue development. It was shown that the use of C60FAS led to a reduction in the recovery time of muscle contraction force and an increase in the time of active work in muscles during fatigue development in anes‐ thetized Wistar rats The i.p. injection of the dopamine (DA) receptor agonist apomorphine (AM), which induc‐ es long‐lasting circular movements in hemiparkinsonic animals, can lead to skeletal muscle fatigue, and us‐ ing C60 fullerene as a powerful antioxidant will induce changes in the movement of the rats for 1 h. The aim of this study was to reveal the preventive effect of C60FAS on the development of muscle fatigue during long‐lasting rotational movements induced by AM in non‐anesthetized animals with EH
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