Abstract
BackgroundBioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine C60 fullerene aqueous colloid solution (C60FAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats.ResultsDuring fatigue development, we observed decrease in the muscle effort level before C60FAS administration. After the application of C60FAS, a slower effort decrease, followed by the prolonged retention of a certain level, was recorded. An analysis of the metabolic process changes accompanying muscle fatigue showed an increase in the oxidative stress markers H2O2 (hydrogen peroxide) and TBARS (thiobarbituric acid reactive substances) in relation to the intact muscles. After C60FAS administration, the TBARS content and H2O2 level were decreased. The endogenous antioxidant system demonstrated a similar effect because the GSH (reduced glutathione) in the muscles and the CAT (catalase) enzyme activity were increased during fatigue.ConclusionsC60FAS leads to reduction in the recovery time of the muscle contraction force and to increase in the time of active muscle functioning before appearance of steady fatigue effects. Therefore, it is possible that C60FAS affects the prooxidant-antioxidant muscle tissue homeostasis, subsequently increasing muscle endurance.
Highlights
Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, serving by a powerful scavenger of reactive oxygen species to many natural antioxidants, widely used to decrease the muscle fatigue effects
The results obtained are consistent with the theoretical calculations and experimental measurements [20, 21, 31, 32] and demonstrate the polydispersity of the pristine C60 fullerene aqueous colloid solution (C60FAS) used in our study
We can calculate the radius of particles, R, present in the C60FAS according to well-known equation Rg2 = 0.6R2 assuming of homogeneous and spherical of C60 fullerene clusters
Summary
Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, serving by a powerful scavenger of reactive oxygen species to many natural antioxidants, widely used to decrease the muscle fatigue effects. C60 fullerene bonds with up to six electrons, can serve as a powerful scavenger of ROS [13,14,15], and is superior to the majority of natural antioxidants, including vitamins C and E and carotenoids, in regard to its antioxidant capacity. As a result, it prevents oxidative stress dissemination in thymocytes [16] and shows a protective effect following the ischemia–reperfusion injury of skeletal muscle [17]. The use of C60 fullerenes may have a powerful antioxidant effect on the contractile apparatus of striated muscle, thereby facilitating its functional recovery after experimentally induced fatigue
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