Abstract
HERE IS INCREASING evidence for a pathogenetic role of humoral immunity in acute kidney allograft rejection. The complement split product C4d represents an attractive marker for antibody-mediated graft injury. Capillary C4d deposits in kidney allograft biopsies were found to be associated with the appearance of posttransplant anti-donor antibodies 1 and with poor graft outcome. 2 The objective of this retrospective study was to analyze the incidence and clinical relevance of C4d deposition in biopsies not selected for a specific type of allograft dysfunction with special emphasis on correlations between C4d staining patterns and histopathologic features of acute rejection.
Published Version
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