Abstract
Various kinds of Michael acceptors could be introduced at the C132-position in an epimeric mixture of methyl pheophorbides-[Formula: see text]/[Formula: see text]’ under basic conditions. The isolated yields and C132-epimeric ratios ([Formula: see text]/[Formula: see text] > 1) of the adducts depended on the electron-withdrawing group in the Michael acceptors. Some Michael acceptors possessing a less electron-withdrawing group could not react with methyl pheophorbides-[Formula: see text]/[Formula: see text]’. Neither α- nor β-substituted Michael acceptors gave the desired products. On the other hand, a Michael acceptor possessing a terminal alkyne was introduced as the C132-alkenyl moiety. We here report the scope and limitations of the Michael addition reactions for chlorophyll-[Formula: see text] derivatives.
Published Version
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