Abstract
and potentially at greater risk of developing early restenosis/ reocclusion after femoropopliteal percutaneous transluminal angioplasty (PTA). Methods: In 44 patients with atherosclerotic peripheral artery disease undergoing PTA blood was obtained 1 day before (sample 1), during (samples 2, 3, 4 and 5) and 1 day after PTA (sample 6). Samples 3 and 5 were arterial, others were venous. Besides OHP, Overall Coagulation Potential (OCP) was determined in plasma after addition of thrombin only and Overall Fibrinolitic Potential (OFP) was calculated as [(OCP-OHP)/OCP]x100. In samples obtained during PTA unfractionated heparin applied during the procedure was neutralized with polybrene. One month after PTA restenosis was diagnosed in 10 patients in 17 patients treated artery remained patent, while other 17 will be examined in the following weeks. Results: In all 44 samples 1 and 6 OHP and OCP were significantly higher (pb0.001) compared to samples 2–5, while no difference was observed for OFP. OHP, OCP and OFP in samples 1 did not differ significantly from samples 6 and no difference was observed between arterial (3, 5) and venous (2, 4) blood samples. OHP, OCP and OFP of patients with restenosis did not differ significantly from patients without restenosis (Table).
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