Abstract
Abstract Background: Inflammation is a major component of the response to tissue injury caused by myocardial infarction. High-sensitivity C-reactive protein (hs-CRP) levels might be a simple marker of the severity of this inflammatory response, providing prognostic information. Objective: To associate hs-CRP level on admission and other clinical characteristics with in-hospital mortality of patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: A retrospective cohort study of patients admitted with STEMI was carried out. Patients were analyzed regarding clinical characteristics, reperfusion therapy, hs-CRP on admission and outcomes. Continuous variables were analyzed by non-parametric Mann-Whitney U test and categorical variables by chi-square test. A p value of < 0.05 was considered statistically significant. Results: Of the 118 patients analyzed, 20 died during hospitalization. Higher levels of hs-CRP (p = 0.001) and older ages (p = 0.003) were observed among those patients who died. Logistic regression showed that a one unit increase in hs-CRP increased the risk of death by 15% (p = 0.0017), after adjustment for established risk factors. Similarly, each one-year increase in age increases the risk of death by 6.6% (p = 0.003). Conclusion: Our results demonstrate a strong association between hs-CRP obtained on admission and in-hospital mortality after STEMI. It suggests that hs-CRP can be a marker of inflammatory response to myocardial ischemia, providing prognostic information regarding the risk of death.
Highlights
Cardiovascular diseases are the leading cause of mortality and morbidity in the world.[1]
In the early phase of myocardial infarction, High-sensitivity C-reactive protein (hs-C-reactive protein (CRP)) may be a simple marker of the magnitude of the inflammatory response to myocardial ischemia, potentially providing prognostic information regarding the risk of death.[6,8,9]
We aimed to evaluate the association of hs-CRP levels on admission, and other clinical characteristics with occurrence of in-hospital death of patients with acute ST-segment elevation myocardial infarction (STEMI)
Summary
Cardiovascular diseases are the leading cause of mortality and morbidity in the world.[1] Inflammation is thought to be the key mechanism in the pathogenesis of atherosclerosis and the value of assessing the levels of inflammatory biomarkers has risen.[2] Many prospective cohort studies have demonstrated that baseline levels of high-sensitivity C-reactive protein (hs-CRP) in apparently healthy men and women are highly predictive of future risk of heart attack.[3]. Objective: To associate hs-CRP level on admission and other clinical characteristics with in-hospital mortality of patients with acute ST-segment elevation myocardial infarction (STEMI). Conclusion: Our results demonstrate a strong association between hs-CRP obtained on admission and in-hospital mortality after STEMI. It suggests that hs-CRP can be a marker of inflammatory response to myocardial ischemia, providing prognostic information regarding the risk of death. It suggests that hs-CRP can be a marker of inflammatory response to myocardial ischemia, providing prognostic information regarding the risk of death. (Int J Cardiovasc Sci. 2019;32(2)118-124) Keywords: Myocardial Infarction/mortality; C-Reactive Protein; Inflamation; Biomarkers; Hospital Mortality
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
