Abstract
Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP 5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.
Highlights
Schizophrenia is a psychiatric disorder, of prolonged and disabling evolution
We found that the variables: Lymphocyte count, total positive and negative syndrome scale (PANSS) score, PANSS excitement score were independently associated with a CRP> 5 mg/L
We found that patients with elevated CRP had a total PANSS score and scores of subscales: PANSS positive and negative significantly elevated compared to the normal CRP group
Summary
Schizophrenia is a psychiatric disorder, of prolonged and disabling evolution. In Morocco, the National Survey of Prevalence of Mental Disorders in the general population aged 15 and over revealed that 5.6% suffer from a psychotic disorder and that more than 200.000 Moroccans aged 15 and over, suffer from Schizophrenia [1]. The fact that schizophrenia would be one of the most incriminated psychiatric disorder in the acting out is comforted by several data from the scientific literature, schizophrenic subjects show twice an aggressive behavior compared to the general population according to the report of the HAS on psychiatric dangerousness [2]. Aggressive behavior is one of the leading causes of admission to a psychiatric institution and may endanger the caregiver, the patient, and other patients in the ward, The risk of violence would be increased during relapses episodes of manic excitement, hallucinatory episodes or a florid outbreak of symptoms of schizophrenia [3].
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