Abstract
Chronic kidney disease is a major public health concern that affects millions of people globally. Alterations in gut microbiota composition have been observed in patients with chronic kidney disease. Nevertheless, the correlation between the gut microbiota and disease severity has not been investigated. In this study, we performed shot-gun metagenomics sequencing and identified several taxonomic and functional signatures associated with disease severity in patients with chronic kidney disease. We noted that 19 microbial genera were significantly associated with the severity of chronic kidney disease. The butyrate-producing bacteria were reduced in patients with advanced stages of chronic kidney diseases. In addition, functional metagenomics showed that two-component systems, metabolic activity and regulation of co-factor were significantly associated with the disease severity. Our study provides valuable information for the development of microbiota-oriented therapeutic strategies for chronic kidney disease.
Highlights
Chronic kidney disease is a major public health concern that affects millions of people globally
Altered gut microbiota composition has been reported in patients with Chronic kidney disease (CKD), including those with end-stage renal disease (ESRD), compared with healthy controls[7,8]
Stool samples from a total of 52 patients with varying stages of CKD were collected in this study: CKD3A (n = 12), CKD3B (n = 11), CKD4 (n = 15), CKD5 (n = 4) and ESRD (n = 10) (Table 1)
Summary
Chronic kidney disease is a major public health concern that affects millions of people globally. Altered gut microbiota composition has been reported in patients with CKD, including those with end-stage renal disease (ESRD), compared with healthy controls[7,8]. This study was designed to determine the shift in microbial community composition and assess the alteration in microbial functional capacity in CKD patients with different disease severity.
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