Abstract
When rat liver mitochondria were exposed to protamine or butylmalonate, succinate oxidation was inhibited. However, butylmalonate was found to release the inhibitory effect of protamine on succinate oxidation in mitochondria. Electron microscopic study carried out in the present study showed that protamine induced “orthodox” configuration in which the matrix space was maximally expanded eliminating the intracristal space, whereas butylmalonate highly contracted the matrix space thus expanding the intracristal space. Butylmalonate overcame the effect of protamine on mitochondrial configuration, specified above, expanding the intracristal space. The mechanism of the opposite action of butylmalonate in the presence and absence of protamine on succinate oxidation was correlated to the configurational changes of the mitochondrion.
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