Abstract
The effect of tannic acid on succinate oxidation and on succinate and malate translocation has been studied in rat liver mitochondria. Tannic acid inhibits succinate oxidation in mitochondria but not in submitochondrial particles. The inhibition of succinate oxidation appears as competitive by using the double reciprocal plot and as partially competitive by using the Dixon plot. Tannic acid inhibits the swelling of mitochondria on the presence of ammonium succinate or ammonium malate and the valinomycin-induced swelling with succinate as accompanying anion. It is concluded that tannic acid inhibits succinate oxidation by preventing the operation of the carrier of dicarboxylic acids on the mitochondrial membrane. The reported evidence indicates that tannic acid induces a confonnational change reducing the affinity of the carrier for succinate.
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