Abstract
Buspirone produces a dose-dependent but short-lived elevation in striatal dopamine (DA) metabolites in the rat. In vitro , buspirone possesses an affinity similar to sulpiride for DA receptors (3H-spiperone). A moderate affinity for α 1 receptors was also observed while buspirone was inactive at α 2, β, muscarinic and serotonin 2 receptors. This pharmacological profile as well as previous behavioral data indicate that buspirone may be a potential “atypical” neuroleptic.
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