Abstract
Burmese grape, common lime, pomelo, salak, Southern langsat, star fruit, and orange modulate the expression of cytochrome P450 enzymes in mouse livers
Highlights
Fruit and vegetables play a valuable role in the human diet
Jarukamjorn K (2020) Burmese grape, common lime, pomelo, salak, Southern langsat, star fruit, and orange modulate the expression of cytochrome P450 enzymes in mouse livers erythromycin, NADPH, p-aminophenol and the Cytochrome P450s (CYPs) inducers including β-naphthoflavone (BNF), phenobarbital (PB), dexamethasone (Dex) was purchased from Sigma Chemicals
Mouse monoclonal antibodies against Cyp1a1/2, Cyp2b9/10, Cyp3a11 and peroxidase-labelled species-specific IgG were from Santa Cruz Biotechnology (Santa Cruz, CA)
Summary
Fruit and vegetables play a valuable role in the human diet Their antioxidant activity protects against cellular damage caused by exogenous free radicals and toxicants [1]. They aid digestion and the laxative process [2]. Oral bioavailability depends on several factors, including the rate and extent of drug metabolism. Several studies have demonstrated food-drug interactions due to CYP modification, for example the increase and decrease of felodipine bioavailability by grapefruit (Citrus paradisi) juice and orange (Citrus sinensis) juice, respectively [8]. The inhibitory effects of star fruit (Averrhoa carambola) on human CYP3A activity [7] and pomegranate (Punica granatum) on human CYP3A-mediated metabolism of carbamazepine have been reported [12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
