Abstract
1. 1. Regulation of dopamine transporter (DAT) mRNA was studied in rats treated with the DAT blocker bupropion (BUP; 15 or 30 mg/kg tid × 2d), the norepinephrine transporter blocker desipramine (DMI; 10 mg/kg/d × 2d), or saline. 2. 2. mRNA expression was assessed via in situ hybridization histochemistry. 3. 3. BUP and DMI both increased DAT mRNA expression in the ventral tegmental area/substantia nigra. 4. 4. These findings suggest that DAT mRNA expression in the brain may be regulated by both noradrenergic and dopaminergic mechanisms.
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