Abstract
AbstractMultidrug delivery systems are capturing much attention while ingenious drug carriers are drug delivery researchers' pursuit. A method building dual‐polymer nanoparticles (DPNs), one analogous micelle nanoparticle, with double hydrophobic core layers and a hydrophilic shell, is developed by combining co‐axial injection and solvent evaporation using a hydrophobic and an amphiphilic polymer. Hydrophobic drugs can be efficiently and zonally encapsulated in core and/or outer hydrophobic zone of DPN. As a result, DPN can sequentially release drugs and appears stronger growth inhibition to Hela cells and cell uptake than normal drug‐loaded micelles. Moreover, this method is universal to other material combinations of hydrophobic/amphiphilic polymers. Therefore, DPN has potential as one multidrug delivery system.
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