Buchholzia Coriacea Exhibited Antinecrotic, Antioxidant and Anti-Inflammatory Potentials in the Sub-Acute Dose of Paracetamol Induced Toxicity

Olusola Ao

doi:10.26717/bjstr.2020.26.004364

Abstract

This study was designed to investigate the potential ameliorative effect of the ethanolic seed extract of Buchholzia Coriacea in paracetamol-induced toxicities in male wistar rats using N-acetyl cysteine as a standard drug. Thirty-two male wistar rats were used for the study.

Highlights

Liver is a very important organ of the body which is responsible for majority of metabolism needed by the body for good health
The kidney is another important organ of the body which is responsible for maintaining homeostasis in the body and is susceptible to certain drugs, environmental toxicants and protein overload Wasung, et al [3]
Cold extraction method was employed. 500g of the clean, air dried and pulverized plant sample was weighed into extraction jar and 1400ml of analytical grade ethanol was added to the jar containing Buchholzia coriacea

Summary

Introduction

Liver is a very important organ of the body which is responsible for majority of metabolism needed by the body for good health. It makes many of the chemicals required by the body to function normally, it breaks down and detoxifies various metabolites, synthesizes proteins, and produces bio-chemicals necessary for digestion, and it acts as a storage unit Kaplowitz [1]. Most cases of liver and kidney damage occur in people who have taken at least 10-15 grams more than twice the recommended dose of paracetamol (acetaminophen). Some people are more susceptible to acetaminophen toxicity and can experience liver and kidney damage even at the recommended dose. The present study aimed at evaluating the anti-inflammatory, antinecrotic and antioxidant properties of Buchholzia coriacea seeds, which would further enhance its utilization as food or medicine

Materials and Methods

Extraction Procedure

Discussion