Buccal versus Intravaginal Administration of Misoprostol for Labor Induction

Abstract

Objective: The purpose of this study is to compare the efficacy of misoprostol that is administrated in the buccal pouch with the intravaginal route.
 Study design: Ninety eight pregnant women with a singleton live gestation. Bishop score of < 5, gestational ages of > 37 wks were randomized receives misoprostol that would be placed either in the buccal pouch or vagina. In the oral group were initially given 100 μg of misoprostol orally this was repeated every 3-4 hours until occurrence of active and progressive labor while in vaginal group we insert 25 μg in the vagina using a water as a lubricant and the labor and fetal outcome was compared in both groups.
 Results: The hours from drug administration to vaginal delivery were significantly not different between the buccal and vaginal group (1120 ± 128) versus (1412 ± 140) respectively, 28 patient in buccal group versus 35 delivered vaginally in vaginal group. The neonatal outcomes between the two groups were similar and there were no statistical difference between the two groups. (P = not significant). So, buccal misoprostol is effective for cervical ripening as dose the vaginal administration.