Abstract
Buccal flexible films in the form of solid, thin, mucoadhesive patches can be used as dressings separating the mucosal lesion from the environment of the oral cavity. Their advantages include flexibility, application comfort, patient compliance, and better adhesion of the system to the oral mucosa. Moreover, buccal films are able to protect the surface of wound, thus reducing pain and improving effectiveness of treatment of oral diseases. The aim of the experiment was the formulation, development, preparation, and in vitro and in vivo evaluation of mucoadhesive films intended to cover oral mucosal defects. Seven different formulations of flexible patches based on mucoadhesive polymers (carmellose sodium and acid form, polyethylene oxide) were prepared using solvent casting method or method of impregnation, respectively. After in vitro evaluation followed by in vivo testing with 22 healthy volunteer, the film with the best characteristics was selected, and its composition was futher optimized.
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