Abstract
Buccal drug delivery especially refers to the delivery of drugs through the buccal mucosal membrane lining of the oral cavity. For geriatric and pediatric patients who undergo difficulties in swallowing conventional oral solid dosage forms, the buccal film is a better alternative. The buccal film is appropriate for the drugs which experience high first-pass metabolism and is used for enhancing bioavailability with reducing dosing frequency to mouth plasma peak levels, which thus limit side-effects and make it cost-effective. It enhances the efficacy of API in the oral cavity after the contact with less saliva as contrasted to tablets, without chewing and no need for water for administration. This review briefly describes the advantages and limitations of buccal film, an anatomical structure of oral mucosa, highlighting the mechanisms of drug permeation, formulation technologies, methodology in evaluating buccal film, and recent advances of the buccal film as a tool for drug delivery for various treatments.
Highlights
Among the various routes of drug delivery, oral-mucosal drug delivery offers distinct advantages as buccal mucosa is the most suited for local, as well as systemic delivery of drugs [1]
The buccal film is an elegant and effective dosage form with enhanced bioavailability when compared to other dosage forms, as it by-passes the hepatic first-pass metabolism [3]
The present review concludes that the buccal film is that the most accurate and acceptable dosage form, due to higher patient compliance, faster drug delivery system, and bypasses the hepatic first-pass effect and shows enhance bioavailability
Summary
Among the various routes of drug delivery, oral-mucosal drug delivery offers distinct advantages as buccal mucosa is the most suited for local, as well as systemic delivery of drugs [1]. The site of drug administration in oral-mucosa is subdivided into buccal and sublingual mucosa [4]. The buccal mucosa being comparatively immobile mucosa than sublingual mucosa and readily available, it makes it more advantageous for retentive systems used for oral-mucosal drug delivery [6]. The main property of buccal film is that, because of the large surface area of the film, it allows quick wetting of the film which increase the absorption of the drug quickly as compared to the tablets. The buccal mucosa is rich with blood supply, which acts as a perfect and fast site for the absorption of drug [11]
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