Abstract
The Buccal drug delivery system includes drug administration through the buccal mucosa, mainly composed of the lining of the cheeks. Buccal drug delivery system provides a convenient route of administration for both systemic and local drug actions. Buccal films can improve the therapeutic effect of drug by increasing the absorption of drug through oral mucosa which increases the drug bioavailability by reducing the hepatic first pass effect. In recent years, many researchers are working on the delivery of drugs through the oral mucosa which have a high first pass metabolism or degrade in the gastrointestinal tract. Furthermore, buccal drug delivery has a high patient acceptability compared to other non-oral transmucosal routes of drug administration. It provide direct access to the systemic circulation through the internal jugular vein thus avoids acid hydrolysis in the gastrointestinal tract and bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. This article deals with the development and evaluation parameters used at present and future role of the system for the treatment of diseases by incorporating different class of drugs. Peer Review History: Received 2 May 2017; Revised 5 June; Accepted 3 July, Available online 15 July 2017 Academic Editor: Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, amalbgadley@pnu.edu.sa Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Razan Haddad, Jordan University of Science and Technology, Jordan, razanhh@yahoo.com Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, amalbgadley@pnu.edu.sa Similar Articles: BUCCAL DRUG DELIVERY SYSTEM: AN OVERVIEW ABOUT DOSAGE FORMS AND RECENT STUDIES DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES FOR BUCCAL DELIVERY OF PREGABALIN
Highlights
The Buccal drug delivery system includes drug administration through the buccal mucosa, mainly composed of the lining of the cheeks
Bypass of the gastrointestinal tract and hepatic portal system increasing the bioavailability of orally administered drugs that otherwise undergo hepatic first-pass metabolism
A relatively rapid onset of action can be achieved relative to the oral route, and the formulation can be removed if therapy is required to be discontinued as the buccal patches are there
Summary
Amongst the various routes of drug delivery, oral route is considered better for patient. The delivery of drug requires some type of dosage form present in the oral cavity, which release drug and diffuses from the mucosa into the blood flow and is added to the blood circulation. Epithelium: The epithelium, act as a protective layer for the tissues and is divided into: (a) non-keratinized surface in the mucosal lining of the soft palate, the ventral surface of the tongue, the floor of the mouth, alveolar mucosa, vestibule, lips, and cheeks Saliva It is considered as an protective fluid for all tissues of the oral cavity. Reservoir type (Unidirectional) The buccal patch designed in a reservoir system contains a cavity for the drug and additives separate from the adhesive. It should not produce any irritancy, allergy and discoloration or erosion of teeth
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