Abstract
Bromopyruvate functions as an active-site directed irreversible inhibitor of the pyruvate-dehydrogenase complex (PDHc), which has a regulatory function in both the carbohydrate and acetylcholine metabolism in brain tissue. After inhibition of brain PDHc by intraventricular injections of bromopyruvate we found memory deficits in discrimination reversal tasks accompanied by changes in oxidative metabolism, which indicated a reduced PDHc activity together with compensating anaplerotic reactions in the hippocampus but not in fronto-parietal cortex. This animal model may be useful to study biological events in memory and cognition disturbances.
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