Abstract
The thymidine (dT) analog 5-bromodeoxyuridine (BrdU) produces a variety of biological effects in mammalian cells, such as the induction of latent viruses [10], inhibition or induction of differentiated functions [20], and mutagenesis [11]. Because BrdU is such an excellent analog of dT, it is readily phosphorylated and incorporated into mammalian DNA in place of dT. Numerous studies have demonstrated a correlation between the incorporation of BrdU into DNA and the occurrence of its biological effects. As a result, it has been assumed that all or most of the biological effects of BrdU result from the presence of the analog in DNA.
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