Abstract
This study was undertaken to evaluate the oxidative stress induced by bromadiolone toxicity in layers. Birds were divided into two groups. Control group (I) received bromadiolone free feed and group (II) was exposed to bromadiolone (5 mg/kg feed) for seven weeks. Blood samples and organs were collected at the end of the experiment. Bromadiolone exposure resulted in significant rise in lipid peroxidation (LPO) levels in erythrocyte and liver. In addition decreased ( P <0.05) level of reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activities were observed in erythrocyte and liver. Histopathological results revealed mild to severe type of necrosis and degenerative changes in heart and liver of bromadiolone intoxicated animals. In addition histopathological findings of tissues ovary, liver, heart and pancreas also showed generalized haemorrhage. It is therefore concluded that feeding of bromadiolone admixed feed lead to depletion of Vitamin K causing multifocal haemorrhages and oxidative stress and cellular damage in different tissues.
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