Abstract
In 1909, Korbinian Brodmann published his famous parcellation of the cerebral cortex. It is based on regional differences in the laminar architectonic pattern of neurons in preparations stained for cell bodies (cytoarchitecture). The map has become a ‘classic’ in the field of neurobiology. However, from today's state-of-the-art neuroimaging perspective, it is almost impossible to use Brodmann's map as a valid structural guide to functional units in the cortex. This is mainly due to the problematic compatibility of the ‘postmortem world’ of microstructural brain mapping with the ‘in vivo world’ of neuroimaging. A new approach has the great potential to overcome this dilemma and directly correlate microstructure and function in the same living human brains: ‘in vivo Brodmann mapping’ with high-field magnetic resonance imaging.
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