Abstract
Microbiology Fecal microbiota transplantation (FMT) has been successful at treating Clostridium difficile infections, although recent events show there are major risks of antibiotic resistant pathogen transfer (as noted by a recent U.S. Food and Drug Administration alert). FMT is also being investigated to treat bowel cancers and improve therapeutic responses. The gut is not the only site in which the symbiotic microbiota can promote homeostasis. In particular, the vagina contains a specialized microbiota that can be altered after bacterial infection. Lev-Sagie et al. treated five patients with intractable and recurrent bacterial vaginosis with vaginal microbiota transplantation (VMT) from healthy donors. Four of the women underwent long-term remission and reconstitution of a normal microbiota. No adverse effects were seen in this study, indicating that VMT could be tested in randomized clinical trials. Nat. Med. 25 , 1500 (2019).
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