Abstract
Brivaracetam (BRV) is the latest approved antiepileptic drug and acts as a high-affinity Synaptic Vesicle protein2A (SV2A) ligand that exceeds the binding potential of Levetiracetam (LEV). In the European Union, BRV is only approved as an adjunctive therapy for the treatment of Partial-Onset Seizures (POS) with or without secondary generalization, in patients 4 years of age and older with epilepsy, while F.D.A. has recently approved its use as monotherapy in partial-onset seizures in adults. In Phase III clinical trials, BRV has shown efficacy and an adequate safety profile in patients suffering from POS. In additional open-label studies, BRV has demonstrated satisfying results and high retention rates in patients with both focal – onset and genetic generalized epilepsies. The main Treatment-Emergent Adverse Events (TEAEs) observed during the regulatory and open label trials were somnolence, dizziness and headache following by fatigue and nausea. Brivaracetam seems to be an effective, easy to use and safe antiepileptic drug in clinical setting.
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