Abstract

Learning-based methods have been proved to perform well in a variety of areas in the biomedical field, such as biomedical image segmentation, and histopathological image analysis. Deep learning, as the most recently presented approach of learning-based methods, has attracted more and more attention. For instance, massive researches of deep learning methods for image reconstructions of computed tomography (CT) and magnetic resonance imaging (MRI) have been reported, indicating the great potential of deep learning for inverse problems. Optical technology-related medical imaging modalities including diffuse optical tomography (DOT), fluorescence molecular tomography (FMT), bioluminescence tomography (BLT), and photoacoustic tomography (PAT) are also dramatically innovated by introducing learning-based methods, in particular deep learning methods, to obtain better reconstruction results. This review depicts the latest researches on learning-based optical tomography of DOT, FMT, BLT, and PAT. According to the most recent studies, learning-based methods applied in the field of optical tomography are categorized as kernel-based methods and deep learning methods. In this review, the former are regarded as a sort of conventional learning-based methods and the latter are subdivided into model-based methods, post-processing methods, and end-to-end methods. Algorithm as well as data acquisition strategy are discussed in this review. The evaluations of these methods are summarized to illustrate the performance of deep learning-based reconstruction.

Highlights

  • Photons propagating through biological tissues can be collected in vivo by these modalities, indicating the spatial optical properties like absorption coe±cient and scattering coe±cient which can be obtained by all the three methods, or the internal °uorophore distribution which can be obtained by FMT and bioluminescence tomography (BLT) methods.[6,7,8]

  • Since the forward problems and the inverse problems of biomedical optical imaging systems are various and more complex than the aforementioned systems, particular studies for reconstructions which are based on learning methods and focus on di®erent modalities, such as Di®use optical tomography (DOT), FMT, BLT, and photoacoustic tomography (PAT), have been presented recently

  • By replacing the unknowns, which need to be reconstructed, the inverse problems still need to be solved by any reconstruction algorithm

Read more

Summary

Introduction

Di®use optical tomography (DOT), °uorescence molecular tomography (FMT), together with bioluminescence tomography (BLT) are noninvasive modalities for biomedical imaging.[1,2,3,4,5] Photons propagating through biological tissues can be collected in vivo by these modalities, indicating the spatial optical properties like absorption coe±cient and scattering coe±cient which can be obtained by all the three methods, or the internal °uorophore distribution which can be obtained by FMT and BLT methods.[6,7,8] The optical coe±cients, as well as the intensity and lifetime of °uorescence or bioluminescence, are generally in°uenced by oxygen saturation, hemoglobin concentrations and other situations of the tissue These modalities of optical tomography are promising to be adopted in tracing tumors and drug development, and have been paid more and more attention.[1,9].

Kernel-Based Methods
Kernel-based methods for DOT
Kernel-based methods for FMT
Deep Learning Methods for Optical Tomography
Model-based methods for inverse problems
Post-processing methods to rene reconstructions with deep learning
End-to-end methods with deep learning
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call