Abstract
Introduction: This randomized controlled trial study aimed to find the benefits and possible side effects of brewed chicory leaf consumption in non-alcoholic fatty liver disease (NAFLD) patients. MethodsSixty NAFLD patients were randomly allocated into intervention and control groups and consumed brewed chicory leaf made from 15 g chicory leaf along with usual treatment or only the usual treatment, respectively. This study was planned for 12 weeks, but it was stopped in the sixth week due to unexpected side effects. ResultsAfter 6 weeks, total bilirubin, ALT and AST in the intervention group were significantly reduced compared to the control group (p < 0.05). In the intervention group compared to the control group we observed a significant increase in number of red blood cells (0.16 ± 0.33 vs. −0.01 ± 0.27, p = 0.026), platelets (34.00 ± 45.55 vs. 7.96 ± 25.30, p = 0.014), hemoglobin (0.37 ± 0.84 vs. −0.09 ± 0.59, p = 0.018), fasting blood sugar (5.85 ± 8.47 vs. 0.29 ± 6.67, p = 0.017), total cholesterol (14.08 ± 20.80 vs. −1.30 ± 4.42, p = 0.001), low-density lipoprotein (15.36 ± 20.02 vs. −0.17 ± 6.70, p < 0.0001), and a significant decrease in the mean platelet volume (−3.03 ± 1.79 vs. 0.01 ± 0.62, p < 0.0001). DiscussionConsumption of brewed chicory leaf could have unexpected side effects on people with NAFLD. (IRCT20190819044565N2)
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