Abstract
Platelet (PLT) indices have been proposed as potential markers in the assessment of liver fibrosis and exacerbation of liver failure. The aim of our study was to verify mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in alcohol-related liver cirrhosis (ALC) and nonalcoholic fatty liver disease (NAFLD) patients. One hundred forty-two patients with ALC, 92 with NAFLD, and 68 in control group were enrolled in this study. Hematological indices (MPV, PCT, and PDW) and serological (indirect and direct) markers of liver fibrosis (AAR, APRI, FIB-4, GPR, PICP, PIIINP, TGF-α, PDGF-AB, laminin) were measured in each participant. MELD score in ALC patients and NAFLD fibrosis score (NFS) together with BARD score in the NAFLD group were also obtained. Results were compared between research and control groups. Then, a correlation between evaluated indices was performed in study groups. Receiver operating characteristic curves (ROCs) and area under the curve (AUC) values were applied to assess the diagnostic accuracy of measured indices. Significant increase in PDW and decrease in PCT in comparison to controls were noted in examined ALC (60.4% vs. 51.2% and 0.1% vs. 0.21%, respectively, p < 0.0001) and NAFLD (54.75% vs. 51.2% and 0.19 vs. 0.21%, respectively, p < 0.01) patients. Decreased level of MPV was observed in NAFLD group (7.85 fl vs. 8.90 fl, p < 0.0001). Additionally, PCT correlated with NFS (p < 0.0001). Evaluated PLT indices correlated with MELD score (MPV and PDW, p < 0.001; PCT, p < 0.05). They correlated with indirect and direct markers of liver fibrosis in the whole research group, too. PCT was the parameter with the greatest diagnostic accuracy in ALC patients (AUC = 0,839 for cutoff < 0.17%); in NAFLD group, it was MPV (AUC = 0,808 for cutoff < 7.9 fl). PCT in ALC and MPV in NAFLD can be perceived as potential diagnostic markers.
Highlights
Liver cirrhosis (LC), being a final stage of diverse chronic liver diseases (CLDs), constitutes a severe systemic condition with a broad range of life-threatening complications
Median mean platelet volume (MPV) value in alcohol-related liver cirrhosis (ALC) patients was in a normal range; median platelet distribution width (PDW) value turned out to be too high and PCT to be too low
Except median of MPV which was too low, medians of PDW and PCT in the nonalcoholic fatty liver disease (NAFLD) group were in a normal range
Summary
Liver cirrhosis (LC), being a final stage of diverse chronic liver diseases (CLDs), constitutes a severe systemic condition with a broad range of life-threatening complications. Alcohol-related liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) belong to the most common hepatic pathologies with a global burden. ALD is responsible for more than one million deaths yearly, and NAFLD might concern nowadays even. Liver biopsy is still commonly described as a gold standard in the evaluation of fibrosis. This method is connected with several significant limitations, e. G., the assessment only of a tiny part of the liver during a single procedure, verification of biopsy specimen dependent from the pathologist, and serious possible complications (internal bleeding, perforation of biliary tract). The invention of ultrasound and magnetic resonance elastography turned out to be an essential progress in the imaging assessment of liver
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
