Abstract
high temporal resolution TPVM data over the entire NIHR CBRU, Imperial College, London, UK Figure 1 a) Global velocities from 9 short axis slices in one volunteer (each curve represents velocity averaged over a slice). In longitudinal and radial directions one systolic (SL/SR), one early diastolic (DL/DR) and one atrial systolic (ASL/ASR) peak is seen. Longitudinal peaks reduce from base to apex, while radial peaks do not. Two systolic circumferential peaks (C1 and C2) are seen, as well as a diastolic peak (C3) which is negative at base but positive at apex. b) Peak and TTP global velocity values in the mid slice for the healthy volunteers (mean ± SD values shown by red bars), early DCM patient (green crosses) and late DCM patient (blue crosses). Healthy values show small standard deviations (although circumferential peaks are more variable). C3 is not shown as it is very slice-position dependent not always seen in the mid slice. The early stage patient shows normal longitudinal values but reduced radial values, whereas the late stage patient shows reduced peak values in all directions. Simpson et al. Journal of Cardiovascular Magnetic Resonance 2014, 16(Suppl 1):P40 http://www.jcmr-online.com/content/16/S1/P40
Highlights
TPVM is the only MR technique capable of measuring regional myocardial mechanics over the entire cardiac cycle [1,2]
K-space is fully sampled with 8 spiral interleaves (14 ms duration, TR 24 ms) but only 3 spirals are acquired and reconstructed using non-Cartesian SENSE [4] implemented on the Gadgetron GPU framework [5]
Mid and apical short-axis slices were acquired in 10 volunteers and from the mid-slice of 1 early stage DCM patient (LVEF 49%, EDV 188 mL, ESV 96 mL) and one late stage DCM patient (LVEF 21%, EDV 326 mL, ESV 258 mL) on a Siemens Skyra 3T scanner
Summary
TPVM is the only MR technique capable of measuring regional myocardial mechanics over the entire cardiac cycle [1,2]. Previous Cartesian breath-hold TPVM sequences have had low temporal resolution (eg [3]), limiting temporal detail, while navigator sequences are long and difficult to use clinically. This abstract presents a new spiral TPVM sequence which is capable of acquiring. Cardiac cycle within a clinically acceptable breath-hold duration
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