BREAST CANCER SURVIVAL: A HOSPITAL-BASED STUDY IN REGIONAL CANCER CENTRE, BENGALURU

Abstract

Introduction: Breast cancer is one of the most common cancer among Indian Women. The age adjusted rate (AAR) of Breast cancer is 42.1/100000 women in Bengaluru and it is the leading site of cancer in Bengalurian females. The hospital based cancer registry was established in 1983 and is registering around 800 Breast cancer cases per year. Most of them were diagnosed with late stage. The objective of this study is to evaluate Pattern of Care and estimate the Survival rate with respect to different stages, Treatment modalities, ER, PR, HER-2 Status of breast cancer treated only at Kidwai Cancer Institute. A retrospective cohort study was Methodology carried out with 191 Carcinoma Breast cases at a Regional Cancer Centre (Kidwai Memorial Institute of Oncology), Bengaluru. The study started from 2006-2007 and was followed-up until the end of 2020. Five-year survival (60 Months) probabilities were estimated using the Kaplan-Meier and loss adjusted survival analysis method for less than 80% follow-up group for ten years. The log rank test was used to compare the survival between the factors. The overall observed survival rates at 5years Results (60 months) was 72.7%. When analysis was conducted for specic stages, Stage II, Stage III and Stage IV survival rates are 95%, 67% and 17% respectively and is statistically signicant (p<0.001), 39 Patients were dead and 13 Patients were lost for follow-up. The overall survival rate at 10 years was 62.4% and lost for follow-up was 26.5% and death was 27.7%, the Kaplan Meier analysis was unable to be carried out as more than 20% censored cases were seen, hence loss adjusted survival analysis was carried out for 10 years. 89 Patients were alive, 52 patients were dead and 50 patients were lost for follow-up at 10 years. Conclusion: In surgical histopathological nding Estrogen receptor, Progesterone receptor and HER-2 status did not have signicant impact on survival of patients. The post-operative Radiotherapy and combination of modalities of treatment had signicant effect on the long term survival of the patients after adjusting for disease stage.