Breast cancer profile in patients (pts) seen at two Community Hospitals of Buenos Aires,Argentina, born between 1900 and 1970

Abstract

9685 Background: It is known that envirommental and life style changes may play a role in the development of breast cancer.In our country,the patients originally seen with this pathology were Spanish and Italian immigrants who came to Argentina until 1950.We analized the changes that took place with respect tothe age of breast cancer onset and menopause in this population along the last century. Methods: Two thousand and eleven female pts with breast cancer diagnosis (dx),seen at Hospital Rawson (1962–1978) and Hospital Durand (1979–2oo3), were retrospectively analyzed.All of them were born between 1900 and 1970.The following variables were taken into account: date of birth, age and menopausal status at dx.The whole population was divided into three groups based on age : Born between 1900 and 1930 Group A (GA),between 1931 and 1960 Group B (GB) and from 1961 on,Group C(GC). Results: The overall mean age was 55 +/−13 years (yrs).GA 63+/−11 yrs;GB 50+/−9 yrs; GC 35+/−4 yrs.(GA vs.GB p=0.001).As regards the menopausal status at dx,the relation between pre and postmenopausal women was GA:92/620 pts,GB:550/496 pts and GC:95/4 pts.(GA vs GB p=0.001).The age at dx for premenopausal women was GA:46+/− 6yrs,GB:44+/−6 yrs and GC 35+/− 4yrs.(GA vs. GB p=0.001) and in postmenopausal women :GA 66+/−9 yrs,GB56+/−7 yrs and GC 38 +/−3 yrs (GA vs. GB p=0.001).The time between menopause and dx was 18 yrs for GA and 10 yrs for GB.The number of women with childbearing potential under 40 years old who constituted the High Risk Premenopausal Group (HRPG) were 19,176 and 98 for Groups A,B and C respectively.This HRPG correspondedf to 13% of the total number of cases. Conclusions: In our country,the tnedency clearly shows that women are younger at the time of diagnosis (diferences between age Groups A,B and C) and that there is a predominant increase in the number of women who are premenopausal at diagnosis.The differences among Groups A,B and C are more than 10 years.This not only may reflect the early diagnosis and consultation but also other factors that need yet to be determined.The creation of a National Tumor Database could be the only means to confirm these findings. No significant financial relationships to disclose.