Abstract

BackgroundThe background parenchymal enhancement at breast magnetic resonance imaging use to predict breast cancer attracts many searchers to draw a possible relationship. However, the results of their relationships were conflicting. This meta-analysis was performed to assess breast cancer frequency associations with background parenchymal enhancement.MethodsA systematic literature search up to January 2020 was performed to detect studies recording associations between breast cancer frequency and background parenchymal enhancement. We found thirteen studies including 13,788 women at the start with 4046 breast cancer. We calculated the odds ratio (OR) and the 95% confidence intervals (CIs) between breast cancer frequency and background parenchymal enhancement by the dichotomous technique with a random or fixed-effect model.ResultsWomen with minimal or mild background parenchymal enhancement at breast magnetic resonance imaging did not have any risk of breast cancer compared to control women (OR, 1.20; 95% CI 0.54–2.67). However, high background parenchymal enhancement at breast magnetic resonance imaging (OR, 2.66; 95% CI 1.36–5.19) and moderate (OR, 2.51; 95% CI 1.49–4.21) was associated with a significantly higher rate of breast cancer frequency compared to control women.ConclusionsOur meta-analysis showed that the women with high and moderate background parenchymal enhancement at breast magnetic resonance imaging have higher risks, up to 2.66 fold, of breast cancer. We suggest that women with high or moderate background parenchymal enhancement at breast magnetic resonance imaging to be scheduled for more frequent follow-up and screening for breast cancer to avoid any complications.

Highlights

  • The background parenchymal enhancement at breast magnetic resonance imaging use to predict breast cancer attracts many searchers to draw a possible relationship

  • The number of breast cancer associated with background parenchymal enhancement ranged from 14 to 540. 9 studies reported data stratified women by minimal or mild background parenchymal enhancement (Minimal and mild were represented separately in some studies and together in some studies; we decided to show them here together to avoid any inconsistency); 11 studies were with moderate background parenchymal enhancement; and 11 studies were with high background parenchymal enhancement in association with breast cancers frequency

  • 8 studies observed higher breast cancer frequency associated with high background parenchymal enhancement and 8 studies with moderate background parenchymal enhancement

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Summary

Introduction

The background parenchymal enhancement at breast magnetic resonance imaging use to predict breast cancer attracts many searchers to draw a possible relationship. The results of their relationships were conflicting. This meta-analysis was performed to assess breast cancer frequency associations with background parenchymal enhancement. The level of normal fibroglandular tissue that enhances the breast magnetic resonance imaging is recognized as background parenchymal enhancement [1, 2]

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