Brazilian Amazon Traditional Medicine and the Treatment of Difficult to Heal Leishmaniasis Wounds with Copaifera.

Kelly Cristina Oliveira De Albuquerque,Andreza Do Socorro Silva Da Veiga,Andrey Moacir Do Rosário Marinho,João Victor Da Silva E Silva,Erica Vanessa Souza Costa,Maria Fâni Dolabela,Heliton Patrick Cordovil Brigido,Sandro Percário,Erica Patrícia Dos Reis Ferreira

doi:10.1155/2017/8350320

Kelly Cristina Oliveira De Albuquerque, Andreza Do Socorro Silva Da Veiga + Show 7 more

Open Access

https://doi.org/10.1155/2017/8350320

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Abstract

The present study describes the use of the traditional species Copaifera for treating wounds, such as ulcers scarring and antileishmanial wounds. It also relates phytochemical studies, evaluation of the leishmanicidal activity, and toxicity. The species of Copaifera with a higher incidence in the Amazon region are Copaifera officinalis, Copaifera reticulata, Copaifera multijuga Hayne. The copaiba oil is used in the Amazon's traditional medicine, especially as anti-inflammatory ingredient, in ulcers healing, and in scarring and for leishmaniasis. Chemical studies have shown that these oils contain diterpenes and sesquiterpenes. The copaiba oil and terpenes isolated have antiparasitic activity, more promising in the amastigote form of L. amazonensis. This activity is probably related to changes in the cell membrane and mitochondria. The oil showed low cytotoxicity and genotoxicity. Furthermore, it may interfere with immune response to infection and also has a healing effect. In summary, the copaiba oil is promising as leishmanicidal agent.

Highlights

In history, many civilizations have left traces of their culture on objects; there were expressed diseases that affected them
This study describes the traditional use of different species of Copaifera in the treatment of wounds, such as wound healing and leishmaniasis
The chemical composition variations of C. reticulata and the concentration of the main volatile compounds were identified by gas chromatography-mass spectrometry (GCMS)

Summary

Introduction

Many civilizations have left traces of their culture on objects; there were expressed diseases that affected them. Many phytochemical studies have been conducted with species Copaifera and identified several sesquiterpenes (Figure 1) [28,29,30,31,32,33,34] and diterpenes clerodanes (Figure 2) [35,36,37,38,39,40], and labdanes (Figure 2) [34, 39,40,41,42,43]. This study describes the traditional use of different species of Copaifera in the treatment of wounds, such as wound healing and leishmaniasis. It relates this information to phytochemical studies and evaluation of activity and toxicity

Copaifera’s Traditional Use in the Treatment of Wounds and Leishmaniasis

Copaifera’s Traditional Use Validation

Findings

Conclusions