Abstract
Brain-wide imaging of neurons in action.
Highlights
Whole-brain functional imaging at cellular resolution using light-sheet by Ahrens, M
The physical substrates comprising the brain, including neurophysiology, ion gradients, neurotransmitter release, and the molecules involved in action potential firing have been studied since Hodgkin and Huxley developed the squid giant axon model in 1952 Hodgkin et al (1952)
The genetically encoded reporters are derived from fusing the Ca2+-binding domain from calmodulin, another peptide domain, and a circularly permuted green fluorescent protein (GFP) whose fluorescence properties are modulated by the Ca2+ sensing interaction
Summary
Whole-brain functional imaging at cellular resolution using light-sheet by Ahrens, M. Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light by Schrödel, T., Prevedel, R., Aumayr, K., Zimmer, M., and Vaziri, A. In the March and September 2013 issues of Nature Methods, Ahrens et al (2013) and Schrödel et al (2013) describe whole-brain functional imaging at the single-neuron level in two model organisms adapting two fluorescence microscopy techniques.
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