Brain tumor types induced by the Schmidt-Ruppin strain of Rous sarcoma virus in inbred Fischer rats.

Abstract

The Schmidt-Ruppin strain of Rous sarcoma virus has been shown to induce neuroectodermal and mesenchymal tumors of the brain of inbred CDF Fischer rats. The inoculation of 105 FFU of virus into the cerebrum of 2 day old rats was followed by 96% incidence of tumor growth after a latency period of 3 months. Twenty-four of twenty-five inoculated animals developed tumors, all of which were primary intracerebral neoplasms. They fell into three main groups: gliomas 60%, sarcomas 31%, gliosarcomas 9%. Of the 34 gliomas induced, 28 (84%) were astrocytic, and there was one oligodendroglioma, 2 mixed gliomas, and 3 ependymoma-like tumors. The advantages of this brain tumor model are a high glioma incidence, and a short induction time in a commercially available strain of inbred Fischer rats previously shown to be susceptible to the neuro-oncogenic action of resorptive chemical carcinogens.