Abstract
Publisher Summary This chapter describes the behavioral and biochemical differentiation of responses to footshock in rats. Norepinephrine (NE) turnover and metabolism in the brain stem of male Long-Evans rats subjected to electric footshock either with or without another rat are studied. Turnover of brain stem norepinephrine was estimated over the one hour period after Shock, and Fighting rats were removed from the shock chamber. In contrast to the lack of change in fighting rats observed immediately following shock presentation, norepinephrine turnover over the subsequent hour was increased substantially. Conversely, 3H-norepinephrine turnover in brain stem of Shock rats, which increased during the shock period itself, was significantly slower than both Control and fighting group norepinephrine turnover. These results clearly differentiate the two groups exposed to electric footshock, whether on a biochemical, or a behavioral basis, and suggest that brain stem norepinephrine containing neurons participate actively in the behavioral responses evoked by electric footshock.
Published Version
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