Brain Network for the Core Deficits of Semantic Dementia: A Neural Network Connectivity-Behavior Mapping Study.

Yan Chen,Zaizhu Han,Yumei Zhang,Qihao Guo,Yingru Lv,Qing Yang,Junhua Ding,Keliang Chen

doi:10.3389/fnhum.2017.00267

Abstract

Individuals with semantic dementia (SD) typically suffer from selective semantic deficits due to degenerative brain atrophy. Although some brain regions have been found to be correlated with the semantic impairments of SD patients, it is unclear if the damage is actually responsible for SD patients’ semantic disorders because these findings were primarily obtained by examining the roles of local individual regions themselves without considering the influence of other regions that are functionally or structurally connected to the local individual regions. To resolve this problem, we investigated, from the brain network perspective, the relationship between the brain-network measures of regions and connections with semantic performance in 17 SD patients. We found that the severity of semantic deficits of SD patients was significantly correlated with the degree centrality values of the left anterior hippocampus (aHIP). Moreover, the semantic performance of the patients was also significantly correlated with the strength of gray matter functional connectivity of this region and two other regions: the left temporal pole/insula (TP/INS) and the left middle temporal gyrus. We further observed that the strength of the white matter structural connectivity of the left aHIP-left TP/INS tract could effectively predict the semantic performance of SD patients. When we controlled for a wide range of potential confounding factors (e.g., total gray matter volume), the above effects still held well. These findings revealed the critical brain network with the left aHIP as the center that could be contributing to the semantic impairments of SD.

Highlights

Semantic dementia (SD) is a neurodegenerative disease that is characterized by a core symptom of selective semantic deficits (Mesulam et al, 2012) with progressive cerebral atrophy (Hodges et al, 1992; Mummery et al, 2000)
The distributions of degree centrality values between semantic dementia (SD) patients (Figure 1B) and healthy adults (Figure 1C) were similar in the SD-atrophic network except in the left anterior hippocampus (aHIP), in which the values were significantly lower in SD patients (Figure 1D; AlphaSim corrected p < 0.05; Montreal Neurological Institute (MNI) coordinates of cluster peak: −15, −9, −21; cluster size = 106 voxels)
The distribution suggests that the left aHIP was disconnected in the brain networks of SD patients

Summary

Introduction

Semantic dementia (SD) is a neurodegenerative disease that is characterized by a core symptom of selective semantic deficits (Mesulam et al, 2012) with progressive cerebral atrophy (Hodges et al, 1992; Mummery et al, 2000). Brain Network of Semantic Dementia brain regions (e.g., the temporal pole, hippocampus, fusiform gyrus, superior temporal gyrus) are correlated with the semantic disorders of SD (Snowden et al, 1989; Galton et al, 2001; Desgranges et al, 2007; Ding et al, 2016). Oral picture naming Participants were visually presented 140 color pictures, including 20 pictures from each of seven categories, namely, animals, tools, common artifacts, fruits and vegetables, large non-manipulable objects, faces and actions. They were required to correctly verbalize the name of the picture. Their responses were recorded using a digital voice recorder and were manually transcribed off-line

Methods

Results

Discussion

Conclusion